CRIF:MU Acquisition of a Low Temperature Stopped-Flow System with Cyber-Enabled Access

凭借化学研究仪器和设施：多用户计划（CRIF：MU）的这一奖项，塔夫茨大学化学系将获得一种用于快速动力学测量的低温停流仪器。 该仪器的主要用户将是：（1）Elena Rybak-Akimova（2）丹尼尔诺切拉（麻省理工学院），其研究兴趣包括开发用于太阳能转换的化学系统，以及对复杂氧化还原机制的基本理解;（3）威廉·阿姆斯特朗（波士顿学院），其研究兴趣包括理解和模拟光系统II中水氧化复合物的活性位点;（4）John Caradonna（波士顿大学），他正在开发用于绿色烷烃氧化的催化剂;（5）理查德霍尔姆（哈佛），其研究集中在理解固氮酶的固氮作用，以及通过钼-和钨氧化酶的氧原子转移;（6）克里斯托弗康明斯（麻省理工学院），其研究重点是利用大气中的氮和其他氮氧化物，了解原子和基团转移的机制，以及通过与金属中心配位来定时和驯服自由基化学。停流仪器用于研究化学反应的速度，通常是非常快的反应。 这种低温仪器将在很宽的温度范围内工作，温度低至-90摄氏度。 研究生和博士后研究员将接受这种专门方法的培训。 他们将学习在化学研究中使用合理的，基于机制的方法，并将接触到来自多个团体的研究思想，文化和方法。快速动力学方法将被纳入高层次的本科课程。 远程访问数据采集和处理将推进化学研究的网络基础设施。

With this award from the Chemistry Research Instrumentation and Facilities: Multi User program (CRIF:MU), the Chemistry Department at Tufts University will acquire a cryogenic stopped-flow instrument for rapid kinetic measurements. The primary users of this instrument will be: (1) Elena Rybak-Akimova (Tufts University) whose research includes mechanism-based design of selective, efficient, switchable receptors and catalysts for oxidations and small-molecule activation reactions; (2) Daniel Nocera (MIT) whose research interests include developing chemical systems for solar energy conversion, and fundamental understanding of complicated oxidation-reduction mechanisms; (3) William Armstrong (Boston College) whose research interests include understanding and modeling of the active site of the water-oxidizing complex in Photosystem II; (4) John Caradonna (Boston University) who is developing catalysts for green alkane oxidations; (5) Richard Holm (Harvard) whose research is centered around understanding nitrogen fixation by nitrogenase, and oxygen atom transfers by molybdenum- and tungsten oxidative enzymes; (6) Christopher Cummins (MIT) whose research focuses on utilization of atmospheric nitrogen and other pnictogens, understanding the mechanisms of atom and group transfer, and timing and taming radical chemistry through coordination to metal centers.A stopped flow instrument is used to investigate the speed of chemical reactions, often very fast reactions. This cryogenic instrument will operate over a broad temperature range and reach temperatures as low as -90 degrees C. Graduate students and postdoctoral fellows will be trained in this specialized methodology. They will learn to use a rational, mechanism-based approach in chemical research, and will be exposed to research ideas, culture, and methodologies from several groups. Rapid kinetics methodology will be incorporated in upper-level undergraduate courses. The remote access to data acquisition and processing will advance cyber-infrastructure for chemistry research.