CRIF:MU Establishment of a Cyber-Enabled Electron Spin Resonance Spectrometer Facility

得奖后，得克萨斯大学奥斯汀分校的化学和生物化学系将获得一台电子自旋共振(ESR)光谱仪。ESR光谱仪将用于以下研究项目：1)检测电化学或流动混合池中产生的自由基离子，2)在原位电化学实验中检测催化树枝状大分子包裹的纳米颗粒中的自由基，3)金属蛋白体系中自旋活性中间体的研究，4)金属催化剂诱导聚合物氧化的途径研究，5)厌氧微生物酶中氧化还原状态的测量和顺磁性硫中心结构的推断，6)用于结核病治疗的异烟肼氧化转化相关的酰基自由基的检测，7)镧系元素和跨铬系元素配位化合物的表征，和8)氧化还原系统(即蛋白质)的光谱电化学测量。电子自旋共振(ESR)光谱仪通过检测未配对的电子来获得关于分子的分子和电子结构的信息。它还可以用来获取有关自由基寿命的信息，自由基是一种寿命较短的物种，通常对启动肿瘤生长和/或各种化学反应至关重要。这种结构和动态信息可以从正在进行的化学或物理过程中获得，而不影响过程本身。这些研究将在许多领域产生影响，从制造到材料和生物化学。

With this award from the Chemistry Research Instrumentation and Facilities: Multi User program (CRIF:MU), the Department of Chemistry and Biochemistry at the University of Texas at Austin will acquire an Electron Spin Resonance (ESR) spectrometer. The ESR spectrometer will be utilized in research projects including 1) detection of radical ions generated electrochemically or in a flow mixing cell, 2) detection of radicals in catalytic dendrimer-encapsulated nanoparticles in in-situ electrochemical experiments, 3) study of spin-active intermediates in metalloprotein systems, 4) study of the pathways for metal catalyst-induced oxidation of polymers, 5) measurement of the redox states and inference of structures of paramagnetic sulfur centers in enzymes from anaerobic microorganisms, 6) detection of acyl radicals associated with the oxidative transformation of isoniazide for the treatment of tuberculosis, 7) characterization of lanthanide and transactinide coordination compounds, and 8) spectroelectrochemical measurement of redox systems (i.e. proteins).An electron spin resonance (ESR) spectrometer yields information on the molecular and electronic structure of molecules via the detection of unpaired electrons. It may also be used to obtain information about the lifetimes of free radicals, short-lived species that are often essential for the initiation of tumor growth and/or a variety of chemical reactions. Such structural and dynamic information may be obtained from ongoing chemical or physical processes without influencing the process itself. These studies will have an impact in a number of areas, from manufacturing to materials and biological chemistry.