CAREER: The Development of a Patient-Specific Endovascular Graft for Vascular Applications

CBET-0644570 Vande Geest 本研究的目标是使用形状记忆聚合物（SMP）进行患者特定血管内移植物的热机械表征和开发。有四个研究目标：（1）关注由共聚和交联的丙烯酸正叔丁酯和丙烯酸二乙二醇酯组成的SMP，以确定聚合物化学对聚合物的机械性能的依赖性，（2）设计其机械性能与天然动脉组织的机械性能相匹配的SMP组合物，（3）开发用于医疗装置设计的SMP行为的计算模型，以及（4）优化快速原型制作方法以根据医学成像数据制造患者特定的血管移植物。从长远来看，这项研究将对血管疾病的治疗产生潜在的影响。教育计划的中心是在研究者所在机构开发医疗器械培训证书（MDTC）。建议开展三项活动：（1）学生在FDA的暑期实习，作为其医疗器械奖学金计划的一部分，（2）在研究者实验室的研究经验，以及（3）参加研究者的生物力学工程课程。

CBET-0644570 Vande Geest The goal of this research is to perform thermomechanical characterization and development of a patient-specific endovascular graft using shape memory polymers (SMPs). There are four research objectives: (1) focus on a SMP that consists of copolymerized and crosslinked n-tertbutylacrylate and diethyleneglycol acrylate, to determine the dependence of polymer chemistry on the mechanical properties of polymers, (2) design a SMP composition whose mechanical properties match those of the native arterial tissue, (3) develop computational models of SMP behavior for use in medical device design, and (4) optimize rapid prototyping methods to fabricate patient specific vascular grafts from medical imaging data. In the long term, the research will potentially impact the treatment of vascular diseases.The educational program centers on the development of a Medical Device Training Certificate (MDTC) at the investigator's institution. Three activities are proposed: (1) a summer internship for students at the FDA as part of their Medical Device Fellowship program, (2) research experience in the investigator's laboratory, and (3) enrollment in the investigator's course of Biomechanical Engineering.