Structure-Reactivity Relationships in Carbanion Chemistry

通过这个奖项，有机化学和高分子化学项目支持了康奈尔大学的大卫·B·科勒姆教授的工作。这项研究将涉及有机锂试剂在各种溶剂中的结构和反应性的研究，这些溶剂通常用于这些物种的反应。这些试剂在溶液中聚集的方式以及这如何影响它们的反应将被研究。其中一些有机锂试剂用于轮胎工业，用于引发聚合以制造合成橡胶，而另一些用于制药工业，用于制备具有重要药用价值的化合物。更广泛的影响。开展的工作对制药业产生了直接影响，与赛诺菲-安万特、辉瑞、默克、杜邦制药和先灵葆雅的合作就是明证。这些努力与许多药物合成有关，包括Sustiva(抗艾滋病)、Chantix(反吸烟)和otamixaban(用于治疗急性冠状动脉事件)。这些行业合作将使学生和博士后伙伴与参与这些合作的公司直接接触，这将为他们开始独立职业生涯提供宝贵的知识，特别是在工业部门。该协会还将继续为制药过程化学家提供短期课程(迄今已超过20门)。与这些公司的互动也将影响康奈尔大学“扩大你的视野计划”背景下的K-12教育，这是一个旨在向中学女生推广科学的校园计划。对该项目的相当大比例的支持来自，并将继续来自科勒姆教授的合作者和产业界联系人。

With this award, the Organic and Macromolecular Chemistry Program supports the work of Professor David B. Collum of Cornell University. This research will involve the study of the structure and reactivity of organolithium reagents in a variety of the solvents typically used for reactions of these species. The way in which these reagents aggregate in solution and how this affects their reactions will be examined. Some of these organolithium reagents are used in the tire industry to initiate polymerization to make synthetic rubber while others are used in the pharmaceutical industry to prepare medicinally important compounds. Broader Impacts. The work carried out has a direct impact on the pharmaceutical industry as evidenced by collaborations with sanofi-Aventis, Pfizer, Merck, Dupont Pharmaceuticals, and Schering-Plough. These efforts are affiliated with a number of drug syntheses including Sustiva (anti-Aids), Chantix (anti-smoking), and Otamixaban (for treatment of acute coronary events). These industrial collaborations will afford students and postdoctoral associates direct contact with the companies involved in these collaborations which will provide them with valuable knowledge when they begin their independent careers especially in the industrial sector. The PI will also continue to give short courses (over twenty to date) to pharmaceutical process chemists. The interactions with these companies will also impact K-12 education in the context of Cornell's "Expanding Your Horizons Program," an on-campus program to promote science to girls in middle school. A considerable percentage of the support for this program comes from, and will continue to come from, Prof. Collum's collaborators and contacts in industry.