Development of Titanium Catalyzed Reactions for Multicomponent Couplings and Heterocyclic Synthesis

密歇根州立大学的Aaron Odom教授受到无机、生物无机和有机金属化学项目的支持，致力于开发催化C-N键形成反应，特别是那些与杂环合成相关的框架结构。正在探索的中心反应是烯烃和炔的氢胺化和氢肼化使用钛催化剂与吡咯基辅助配体。新的方案也正在制定三组分偶联反应，将联氨、异腈和炔试剂结合在一起。通过原子高效偶联方法形成杂环产品为本项目提供了基础，该项目的特点是在烯烃或炔上添加胺或肼。该项目的广泛影响还包括培养学生在无机和有机机械化学方面的能力，并教授学生复杂的实验技术，包括多核磁共振、动力学和x射线衍射。

Professor Aaron Odom of Michigan State University is supported by the Inorganic, Bioinorganic and Organometallic Chemistry program to develop catalytic C-N bond forming reactions, particularly those that construct frameworks relevant to heterocyclic synthesis. The central reactions being explored are hydroamination and hydrohydrazination of olefins and alkynes using titanium catalysts with pyrrolyl based ancillary ligands. New protocols are also being developed for three component coupling reactions that bring together hydrazine, isonitrile and alkyne reagents.Formation of heterocyclic products via atom efficient coupling methodologies provides the foundation for this project that features the addition of either an amine or hydrazine to an alkene or an alkyne. The broader impacts of this project also include training students in both inorganic and organic mechanistic chemistry and in teaching students sophisticated experimental techniques encompassing multinuclear NMR, kinetics, and x-ray diffraction.