gamma-Hydroxy-alpha,beta-Acetylenic Esters: Asymmetric Synthesis and Application

通过这个奖项，有机化学和高分子化学项目支持了弗吉尼亚大学李普教授的工作。本研究致力于开发催化体系，用于烯醇酸盐与醛的不对称加成反应，以制备合成有用的中间体，用于全合成具有潜在医学应用的化合物。更广泛的影响：这项研究的更广泛的影响被认为是极好的，特别是由于涉及到高中生。PI正在开发的合成方法也将在合成医学上有用的化合物方面有用。

With this award, the Organic and Macromolecular Chemistry Program supports the work of Professor Li Pu from the University of Virginia. This research is focused on the development of catalytic systems for the enantioselective addition of enolates to aldehydes to prepare synthetically useful intermediates for total syntheses of compounds with possible medical applications. Broader Impacts: The Broader Impacts of this research is considered to be excellent, especially due to the outreach to high school students. The synthetic methods being developed by the pI will also be useful in the synthesis of medicinally useful compounds.