Synthesis and Investigation of New Core-Shell Nanoparticles as Molecular Carrier Systems

这项联合计划的目的是开发新型树枝状核-壳纳米载体的有效合成，并系统地研究分子结构对其在水体系中包裹和传输疏水分子的影响。通过结合关组(美国加州大学欧文分校)一锅法合成具有可控拓扑结构的疏水性聚烯烃核的专业知识和HAAG小组(德国柏林自由大学)高效合成亲水性和生物相容性聚甘油壳的专业知识，拟议的研究旨在开发合成核壳纳米载体的有效方法，并揭示所产生的新的两亲性分子结构的基本结构-性质信息。从这项研究中获得的对结构-性质关系的理解将为设计高效的分子纳米载体提供关键的见解，这些分子纳米载体可能会在墨水配方和药物输送方面找到潜在的应用。通过这个奖项，有机和高分子化学计划和国际科学与工程办公室正在支持加州大学欧文分校化学系的关志斌教授的研究。这一奖项与德国联邦理工学院(DFG)为德国柏林自由大学的Rainer Haag教授设立的合作奖项相协调。关教授和哈格教授的研究工作围绕着开发简便的合成方法来制备树枝状聚合物。这种化学方法将有助于环境友好的聚合物合成方法，因为这种方法是高效的。该方法的成功开发将对制药行业的药物输送和化工行业的染料胶囊产生影响。

The objective of this joint proposal is to develop efficient syntheses for new dendritic core-shell nanocarriers and to systematically investigate the effects of molecular architecture on their encapsulation and transport of hydrophobic molecules in aqueous systems. By combining the expertise of the Guan group (UC Irvine, USA) for one-pot synthesis of hydrophobic polyolefin cores with controllable topologies and the Haag group (Freie Universitaet Berlin, Germany) for efficient synthesis of hydrophilic and biocompatible polyglycerol shells, the proposed study intends to develop efficient methodology for the synthesis of core-shell nanocarriers and to reveal basic structure-property information on the resulting new amphiphilic molecular architectures. The understanding of structure-property relationships gained from this study will provide critical insight for designing highly efficient molecular nanocarriers that may find potential applications for ink formulation and drug delivery.With this award, the Organic and Macromolecular Chemistry Program and the Office of International Science and Engineering are supporting the research of Professor Zhibin Guan of the Department of Chemistry at the University of California, Irvine. This award coordinates with a collaborative award funded by Deutsche Forschungsgemeinschaft (DFG) for Professor Rainer Haag, Freie Universitaet Berlin, Germany. Professors Guan and Haag's research efforts revolve around the development of facile synthetic methods for the preparation of dendritic polymers. Such chemistry will contribute to environmentally benign methods for polymer synthesis as the method is highly efficient. Successful development of the methodology will have an impact on drug delivery for pharmaceutical industries and on dye encapsulation for chemical industries.