UBM-Group: Undergraduate Training and Research in Applied Mathematics and Biological Sciences

该项目是建立在现有的应用数学-生物学本科专业的基础上，为大三和大四的本科生提供应用数学和生物学的沉浸式研究体验。来自应用数学和生物学背景的学生团队正在从事生理学和基因组学方面的联合项目。这些项目都是研究人员的活跃研究领域，涵盖了人体循环和调节血流的多尺度动力学，从动脉水平到维持止血的单个血细胞的动力学;细胞和细胞有机体的动力学;以及基因和基因功能的分子生物学。学生与教师顾问一起工作，并与研究生和博士后合作，参加定期的研究会议和研讨会，以及为所有项目参与者举行的每月小组会议。学生还参与提交论文，用于会议演示或期刊出版。该项目的工作是协调与最近推出的课程和指导的学生，它是吸引本科生和教师一起工作的创新和具有挑战性的问题。智力的优点和教育：近年来，在生物系统的定量分析，需要在我们如何教育本科生一个新的眼光爆炸。该项目满足了为他们提供数学和生物科学背景的需要，这将使他们成为未来研究生课程的新一代。在多尺度模拟和科学计算（包括连续统和原子论）、动力系统以及应用于基因组学和基因表达网络的统计方法方面都取得了重大进展。其中大部分仍然只有研究生才能接触到，但围绕着他们所包含的主题的兴奋是吸引本科生参与研究的强大动力。 更广泛的影响：新课程的开发，研究项目和应用数学-生物学浓度的制定将是宝贵的资源，将与其他人在NSF-UBM计划中共享，并更普遍地通过基于网络的链接。本科生也能够参加一个既定的推广计划，为当地高中学生，与他们分享他们的经验和动机。

This project is building on an existing undergraduate major in Applied Mathematics - Biology by providing an immersive research experience in applied mathematics and biology for undergraduates in their junior and senior years. Student teams, drawn from both applied mathematics and biology backgrounds, are working on joint projects in physiology and in genomics. The projects, all active research areas of the investigators, cover the human circulation and the multi-scale dynamics that regulate blood flow, from the arterial level to the dynamics of individual blood cells in maintaining hemostasis; the dynamics of cells and cellular organisms; and the molecular biology of genes and gene function. Students work with faculty advisors and alongside graduate students and post-doctoral associates, participating in regular research meetings and seminars as well as a monthly group meeting for all the project participants. Students also participate in submission of papers for conference presentation or journal publication. The project work is coordinated with recently introduced courses and mentoring of the students and it is drawing together undergraduate students and faculty to work on innovative and challenging problems.Intellectual Merit and Education: There has been an explosion in recent years in the quantified analysis of biological systems that requires a new look at how we educate undergraduates. This project meets the need to provide them with a background in mathematics and biological science that will prepare them as a new generation for future graduate level programs. There have been major advances in multi-scale simulations and scientific computing - both continuum and atomistic, dynamical systems, and the statistical methods applied to genomics and gene expression networks. Much of this is still only accessible to graduate students yet the excitement surrounding the topics they encompass are powerful motivations for engaging undergraduate students in research. Broader Impact: The development of new courses, research projects and the formulation of the Applied Mathematics-Biology concentration will be valuable resources that will be shared with others in the NSF-UBM program and more generally through web-based links. The undergraduate students are also able to participate in an established outreach program for local high school students, sharing with them their experience and motivation.