SGER: Hard Tissue Research On Sub-Saharan Africans Of Known Life History

这项研究的目标是建立第一个已知生活史的撒哈拉以南非洲人硬组织数据库，用于比较区域人类矿化组织生物学研究。 骨骼样本将来自马拉维大学医学院（UMCOM;布兰太尔，马拉维）大体解剖尸体采集的个体。 该组织库将补充维多利亚法医学研究所（VIFM;墨尔本，澳大利亚）的欧洲裔人组织库，并与之进行比较。 来自10名个体的试验性样本将包括大腿和小腿、脚、上臂和下臂、手、脊柱、肋骨架和下颌。 一个具体目标是从近亲提供了预计会影响骨骼结构的无与伦比的生活史细节（例如年龄、性别、身高、体重、职业、重大疾病、产次等）的个人收集骨骼和牙齿样本。 另一个目的是提供非洲和欧洲区域人群之间组织特性差异的第一个高分辨率比较。 由于膳食钙摄入量低，预计UMCOM矿化密度将低于年龄/性别匹配的VIFM个体。 与VIFM城市居民观察到的高变异性相比，UMCOM个体预计具有更明显的股骨胶原纤维取向模式，与更高的平均终身工作量相关;记录UMCOM个体的职业史将有助于本研究。 牙齿组织学预计将提供一个健康状况UMCOM个人的指标，比较记录的生活史细节和骨成分。

The goal of this research is to create the first hard tissue data bank of sub-Saharan Africans of known life history for comparative regional human mineralized tissue biology research. Skeletal samples will derive from individuals of the University of Malawi College of Medicine (UMCOM; Blantyre, Malawi) gross anatomy cadaver collection. This tissue bank will complement and be compared to that of the Victorian Institute of Forensic Medicine (VIFM; Melbourne, Australia) derived of people of European origin. A pilot sample from 10 individuals will include the upper and lower leg, foot, upper and lower arm, hand, vertebral column, rib cage, and lower jaw. It is one specific aim to collect bone and tooth samples from individuals for whom the next of kin have provided unparalleled life history details anticipated to affect skeletal structure (e.g. age, sex, height, weight, occupation, major illnesses, parity, etc.). It is another aim to provide the first high-resolution comparison of tissue property differences between African and European regional human populations. It is expected that UMCOM mineralization densities will be lower compared to age/sex-matched VIFM individuals due to low dietary calcium intake. Compared to the high variability observed for VIFM urban folk, UMCOM individuals are expected to have a more distinct pattern of femoral collagen fiber orientation relating to higher average lifetime workloads; recorded occupational history for UMCOM individuals will facilitate this study. Dental histology is expected to provide an indication of the health status UMCOM individual for comparing to recorded life history details and bone composition.