CAREER: Time-Resolved Condensed Phase Reaction Dynamics Investigated by Multidimensional Infrared Spectroscopy

该奖项由化学系的实验物理化学计划、分子和细胞生物科学部的分子生物物理学计划和跨学科研究的生物风险基金(VIR)资助，密歇根大学的Kevin J.Kubarych教授、他的博士后研究员以及研究生和本科生正在研究60年时间尺度--飞秒到微秒--的细菌视紫红质光周期的动力学。这些研究的主要工具将是多维红外光谱分析。库巴里奇教授和他的团队的工作的最终目标是发展对生物分子如何运动和执行其独特的生物功能的基本化学理解。细菌视紫红质是一个研究得很好的系统，为新的实验方法提供了一个独特的实验室。尽管研究得很好，但细菌霍普蛋白如何发挥作用仍有许多悬而未决的问题，而库巴里奇教授的研究小组的工作将有助于提供答案。除了他的研究工作，库巴里奇教授还计划将他实验室的尖端技术--飞秒光谱仪器--带入本科教学实验室。

In this award, funded by the Experimental Physical Chemistry Program of the Division of Chemistry, the Molecular Biophysics Program of the Division of Molecular and Cellular Biosciences, and the BIO Venture Fund for Interdisciplinary Research (VIR), Professor Kevin J. Kubarych of the University of Michigan, his postdoctoral fellows and graduate and undergraduate students are investigating the dynamics of the bacteriorhodopsin photocycle over six decades of timescale -- femtosecond to microsecond. The principal tool for these studies will be multidimensional infrared (MDIR) spectroscopy. The ultimate goal of the work by Professor Kubarych and his group is to develop a fundamental chemical understanding of how biomolecules move and perform their unique biological functions. Bacteriorhodopsin is a well-studied system, and presents a unique laboratory for new experimental methods. Although well-studied, there are a number of outstanding questions for how bacteriorhodpsin works, and Prof. Kubarych's group's work will help to provide answers. In addition to his research work, Prof. Kubarych plans to bring cutting-edge technology from his laboratory, in the form of femtosecond spectroscopy instrumentation, into the undergraduate teaching laboratory.