Configurationally stable carbanionic reagents for enantioselective synthesis

有了这个更新奖，有机和高分子化学计划继续支持教授保罗R。弗吉尼亚理工大学化学系的Carlier说。 Carlier教授将继续开发新的对映体纯的第1和第2族有机金属化合物，这些化合物在生成和分子间反应所需的时间内在碳上构型稳定。他还将继续他的研究烯醇化物和烯醇醚是手性和非外消旋仅仅凭借其构象。这类化合物将成为合成药物的重要亲核试剂。此外，这些物种的研究将增加我们的理解所需的结构特征，以防止容易外消旋的C-手性sp3杂化有机金属化合物和构象手性活性intermediate.The提高认识的构型和构象稳定性预期从这个项目产生的天然产物合成，药物化学和合成方法学的发展领域将产生广泛的影响。由于立体化学构型代表了一种类型的信息，在这里获得的见解可能有一天在分子电子学中证明是有用的。 强调将机械和计算研究与新的反应发现相结合，为本科生，博士生和研究生提供了良好的培训。学生和博士后同事。

With this renewal award, the Organic and Macromolecular Chemistry Program continues to support the work of Professor Paul R. Carlier of the Department of Chemistry, Virginia Tech. Professor Carlier will continue to develop new enantiopure group 1 and 2 organometallics that are configurationally stable at carbon within the time required for their generation and intermolecular reaction. He will also continue his investigations of enolates and enol ethers that are chiral and non-racemic solely by virtue of their conformation. These species will be valuable nucleophiles for the synthesis of pharmaceuticals. Furthermore, the studies of these species will increase our understanding of the structural features required to prevent facile racemization of C-chiral sp3-hybridized organometallics and conformationally chiral reactive intermediates.The improved understanding of configurational and conformational stability expected to result from this project should broadly impact the fields of natural product synthesis, pharmaceutical chemistry, and synthetic methodology development. Since stereochemical configuration represents a type of information, the insights gained here may one day prove useful in molecular electronics. The emphasis on integrating mechanistic and computational studies with new reaction discovery provides excellent training for undergraduates, Ph.D. students, and postdoctoral associates.