Understanding Elastomer/Stiff Material Interfaces in Fluidic Environments for Bioanalytical Microdevices

了解弹性体/刚性材料界面在Fluorescent环境中的生物分析MicrodevicesThis项目是弹性体和刚性材料（如玻璃和金属）之间的界面稳定性的实验和理论研究相结合。的中心目标是确定关键参数（如粘附能，压力和尺寸），控制薄膜脱粘在不同的流体环境的存在下。 结果将用于确定几何形状和表面处理，提高流体生物分析微器件的可靠性和性能。 该方法是创建由弹性体膜覆盖的微图案化通道：当不同的流体注入通道时，将对界面稳定性进行量化（使用光学和干涉测量）。该研究将包括现有设备中执行DNA提取，扩增和检测的接口的表征。该计划产生的见解将通过开发用于基因组和蛋白质组学分析的生化操作的微型设备来提供社会效益。控制界面稳定性的能力将不仅提高装置可靠性，而且还能够使用基于定制的界面行为（与直接机械致动相反）打开和关闭的被动特征来实现简化的流体流动控制。 这一发展将促进科学发现（通过扩大微尺度流体操纵的范围）和针对临床应用的便携式设备的有针对性的开发。该项目还承担直接相关的灵活？macroelectronics？，例如通过在柔性弹性体衬底上沉积电子特征而产生的视频显示器。该项目将通过在本科实验室放置研究设备来整合研究和教育，重点是设计，快速原型，材料特性，动力学和化学分离。

Understanding Elastomer/Stiff Material Interfaces in Fluidic Environments for Bioanalytical MicrodevicesThis project is a combined experimental and theoretical study of the stability of interfaces between elastomers and stiff materials (such as glass and metals). The central objective is to identify critical parameters (such as adhesion energy, pressures and dimensions) that control thin film debonding in the presence of different fluidic environments. The results will then be used to identify geometries and surface treatments that improve reliability and performance in fluidic bioanalytical microdevices. The approach is to create micropatterned channels that are capped by elastomer films: interface stability will then be quantified (using optical and interferometric measurements) as different fluids are injected into the channels. This study will include the characterization of interfaces in existing devices that perform DNA extraction, amplification and detection.The insights generated by this program will provide societal benefits by enabling the development microdevices that perform biochemical manipulations for genomic and proteomic analysis. The ability to control interface stability will not only improve device reliability, but also enable simplified fluidic flow control using passive features that open and close based on tailored interface behavior (as opposed to direct mechanical actuation). This development will facilitate both scientific discovery (by broadening the range of fluidic manipulations at the microscale) and the targeted development of portable devices for clinical applications. The project also bears direct relevance for flexible ?macroelectronics?, e.g. video displays that are created by depositing electronic features on flexible elastomer substrates. The project will integrate research and education by placing research devices in undergraduate laboratories focusing on design, rapid prototyping, material properties, dynamics and chemical separations.