MRI: Acquisition of Genomic Sequencing Instrumentation

新墨西哥州州立大学（NMSU）已获得国家科学基金会的资助，以获得一种称为乳液PCR焦磷酸测序的基因组测序的变革性新技术形式的主要研究仪器。 这项新技术于三年前首次发明，将DNA测序的时间和成本降低到现有技术的1%左右，并允许对环境样本进行探索性遗传表征。 多用户基因组测序核心设施将使NMSU的研究人员能够率先了解1）一些基因的突变如何影响数百个其他基因的表达，2）某些病毒如何改善某些疾病的致病性，3）允许有益细菌在宿主中生存的基因如何改变以允许致病性，4）严重污染和修复土壤中微生物群落的变化，5）驱动植物和昆虫自然种群持续物种形成的突变，和6）非模式生物的基因组水平遗传表征。NMSU是新墨西哥州少数民族占多数的州生物技术教育的领导者，这将是第一个获得emPCR焦磷酸测序技术的少数民族服务机构。 基因组测序核心设施将利用NMSU生物信息学和计算方面的几个现有项目和设施，为学生培养下一代生物技术人才。

New Mexico State University (NMSU) has received funding from the National Science Foundation to acquire major research instrumentation in the form of a transformational new technology of genome sequencing called Emulsion PCR pyrosequencing. First invented barely three years ago, this novel technology reduces the time and cost of DNA sequencing to about 1% of existing technologies and allows exploratory genetic characterization of environmental samples. The multi-user genome sequencing core facility will allow NMSU researchers to pioneer the understanding of 1) how mutations in a few genes can affect the expression of hundreds of others, 2) how certain viruses ameliorate the pathogenicity of some diseases, 3) how genes that allow beneficial bacteria to live in hosts can change to allow pathogenicity, 4) the changes in microbial communities of severely polluted and remediated soils, 5) mutations that drive ongoing speciation in natural populations of plants and insects, and 6) genome-level genetic characterization of non-model organisms.NMSU is a leader in biotechnology education in the minority-majority state of New Mexico, and it will be the first minority serving institution to acquire emPCR pyrosequencing technology. The genome sequencing core facility will leverage several existing programs and facilities in bioinformatics and computation at NMSU to prepare its students for the next-generation biotechnology workforce.