CAREER: Engineered biomaterial gradients for control of neural cells

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。智力优势：提出的微流体系统独特地允许在生理相关的3D环境中检查因素组合，并对阐明神经发育基础的指导原则以及识别和实施再生疗法具有很大的希望，特别是与生长锥体和丝状体（来自细胞的薄细胞质突出物）动力学的定量建模相结合。更广泛的影响：成千上万的患者遭受中枢神经系统（CNS）创伤和退行性疾病，最终可能从这项研究中受益。每年有200名经济困难的学生被招募到“未来学者”项目中——在这项提议的过程中，有1000名学生被招募进来，而罗格斯大学的家庭社区在人口统计学上主要由代表性不足的群体主导。提议的举措为这些学生提供了独特的机会，这将激发他们对生物医学和组织工程的教育和培训的兴趣，并有助于塑造我们科学和工程界的未来领导者。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).0846328ShreiberIntellectual Merit: The proposed microfluidics system uniquely allows examination of a combinations of factors in a physiologically relevant 3D environment, and holds great promise for elucidating guidance principles that underlay neurodevelopment and for identifying and implementing regenerative therapies, particularly in conjunction with the quantitative modeling of growth cone and filopodial (thin cytoplasmic protusions from the cell) dynamics.Broader Impact: Thousands of patients suffer from central nervous system (CNS) trauma and degenerative disorders and may ultimately benefit from this research. Two hundred economically disadvantaged students are recruited into the Future Scholars program each year - or 1,000 students over the course of this proposal, and Rutgers' home communities are largely dominated demographically by under-represented groups. The proposed initiatives provide unique opportunities to these students that will excite them about education and training in biomedical and tissue engineering and helps shape future leaders of our scientific and engineering communities.