CAREER: Lab-on-a-Chip Systems of Photopatternable Multifunctional Nanocomposite Materials for Cell Detection and Manipulation

职业：用于细胞检测和操作的可光致多功能纳米复合材料芯片实验室系统该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。本研究的目的是提供具有电和生化激活的纳米生物材料解决方案，用于研究生物纳米界面上的细胞反应。该方法是开发可光模式化的多功能纳米复合材料和芯片上的实验室技术，以接口和操纵细胞物体。高通量单细胞捕获和传感以及混合电生化梯度激活将通过使能技术实现。所提出的纳米复合材料将在一个微加工配方中提供独特的光敏性、导电性、特定的生物亲和性和非生物污垢特性。集成了芯片实验室微流体，它提供了一个通用的生物工程平台来检测和操纵复杂生物环境中的特定细胞。进一步研究细胞对统一的生物电和生化信号的反应将有可能导致各种病理过程的诊断和治疗的创新。更广泛的影响研究活动的技术发展和生物学发现将与拟议的教育工作充分结合。一系列专门的教育讲习班将分发给全国的科学教师。将纳米生物工程技术引入K-12实验室？与国际文凭项目合作。此外，与亚洲和欧洲大学的国际推广倡议将根据该计划继续发展，包括年度研究研讨会和夏季合作项目。

CAREER: Lab-on-a-Chip Systems of Photopatternable Multifunctional Nanocomposite Materials for Cell Detection and ManipulationThis award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).ObjectiveThe objective of this research is to deliver nano-biomaterial solutions with both electrical and biochemical activations for investigating cellular responses at bio-nano interfaces. The approach is to develop photopatternable multifunctional nanocomposite materials and lab-on-a-chip techniques to interface and manipulate cellular objects. High-throughput single-cell capture-and-sense and hybrid electrical-and-biochemical gradient activations will be implemented by the enabling technology.Intellectual MeritThe proposed nanocomposite material will offer unique combinational features of photosensitivity, electrical conductivity, specific bio-affinity, and non-biofouling property in one micro-processable formula. Integrated with the lab-on-a-chip microfluidics, it provides a generic bioengineered platform to detect and manipulate the specific cells in an intricate biological environment. Further investigations on cellular responses to the unified bioelectrical and biochemical signaling will potentially lead to innovations of diagnosis and therapeutics in various pathological processes.Broader ImpactTechnical developments and biological discoveries from the research activities will be fully integrated with the proposed educational efforts. A series of dedicated educational workshops will be disseminated to nation-wide science teachers on ?bringing nano-bioengineering technologies into K-12 laboratories?, in collaboration with the International Baccalaureate program. Furthermore, an international outreach initiative with Asian and European universities will continue evolving under the program, including annual research symposium and summer collaborative projects.