CAREER: Physical Aspects of Spindle Self-Organization

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。在该职业奖下，PI将开发和测试细胞骨架组织的一般理论，从而了解中期纺锤体的结构和动力学。该项目将使用荧光和偏振光显微镜，结合磁镊和生物化学方法，研究纺锤体的内部波动，结构和对扰动的反应。这些定量实验的结果将与细胞骨架行为的粗粒度模型的预测进行比较。该项目的教育部分将弥合物理科学家和生物学家之间的差距。这将通过促进跨学科研究，开发本科课程来教授物理学家和工程师的细胞生物学，创建跨学科，研究生水平，基于项目的实验室课程来实现，并将基本的定量方法纳入高中生物学教育。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).Under this CAREER award the PI will develop and test general theories of cytoskeletal organization, and thereby obtain an understanding of the architecture and dynamics of the metaphase spindle. The project will use fluorescence and polarized light microscopy, in conjunction with magnetic tweezers and biochemical approaches, to study the spindle's internal fluctuations, structure, and response to perturbations. The results of these quantitative experiments will be compared with predictions from coarse-grained models of cytoskeletal behavior. The educational component of the project will bridge the gap between physical scientists and biologists. This will be accomplished by promoting interdisciplinary research, developing an undergraduate course to teach cell biology to physicists and engineers, the creation of an interdisciplinary, graduate level, project based laboratory class, and will incorporate basic quantitative methods into biology education at the high school level.