GOALI: High Throughput Experimentation for Reaction Optimization

GOALI项目将整合宾夕法尼亚大学的研究小组和默克、拉威、过程研究部和催化反应发现和开发实验室的成员。 这个GOALI合作计划的焦点是默克？的高通量实验（HTE）设施，这将使这两个小组合作的反应发现和优化。 将探索不仅对制药工业而且对整个化学界都有意义和重要性的基本合成有机反应，以在宾夕法尼亚大学建立一个廉价的永久性HTE设施，该设施将作为其他学术机构可能采用的原型，作为21世纪世纪合成方法开发的基线工具。化学系的有机和大分子计划正在支持宾夕法尼亚大学的杰夫·博德、玛丽莎·科兹洛夫斯基、加里·莫兰德和帕特里克沃尔什教授的小组，使他们能够推进他们在合成方法开发方面的计划。 新的，更有效的和环境友好的化学合成方法的设想，从这个程序？这些方法可以在美国和世界各地的制药，农业和材料科学部门实施。

The GOALI project will integrate research groups at the University of Pennsylvania and members of the Merck, Rahway, Department of Process Research and the Catalytic Reactions Discovery and Development Laboratory. The focal point of this GOALI collaborative program is Merck?s High Throughput Experiments (HTE) facility, which will allow these two groups to collaborate on reaction discovery and optimization. Fundamental synthetic organic reactions of interest and importance not only to the pharmaceutical industry, but to the chemistry community as a whole will be explored to establish an inexpensive, permanent HTE facility at the University of Pennsylvania, which will in turn serve as a prototype that other academic institutions might adopt as a baseline tool for 21st century synthetic methods development.With this award, the Organic and Macromolecular Program of the Division of Chemistry is supporting the groups of Professors Jeff Bode, Marisa Kozlowski, Gary Molander, and Patrick Walsh at the University of Pennsylvania, permitting them to advance their programs in synthetic methods development. Novel, more effective and environmentally sound methods for chemical synthesis are envisioned to arise from this program ? methods that can be implemented in the pharmaceutical, agricultural, and materials sciences sectors in the US and throughout the world.