New Methods for the Synthesis of Biaryl Compounds

该项目将继续开发构建联芳基化合物的新方法。在即将到来的资助期间，研究将集中在三个领域。首先，我们将研究手性二烯类化合物的手性富含对映体方法的研究进展。目前的方法受到底物范围和可扩展性的限制。其次，我们将探索一系列轴向手性联芳基氨基酸化合物的合成及其在标准多肽链中的偶联。轴向手性氨基酸是一类新型的多肽模拟物，将为生物化学家提供新的研究工具。第三，将研究邻硝基苯基炔在进行[3+2]偶极环加成反应中的应用。在此之前，[4+2]环加成反应的可行性已经被证明，而这项新的研究将有助于将这种环加成反应的范围扩大到多芳香族化合物。通过这一奖项，有机和高分子化学项目支持俄勒冈州立大学化学系里奇·卡特教授的研究。卡特教授的研究工作围绕着开发构建复杂多芳香化合物的新方法展开。这类化合物在不对称催化领域有相当大的应用，在制药工业中也是关键的药效团。

This project will continue work on the development of novel methods for the construction of biaryl compounds. During the upcoming funding period, research will be focused in three areas. First, the development of enantioenriched methods for constructing biaryl compounds using chiral dienes will be studied. Current methods are limited by substrate scope and scalability. Second, the synthesis of a series of axially chiral biaryl amino acid compounds and their coupling within standard polypeptide chains will be explored. Axially-chiral amino acids are a new class of peptide mimetics and will provide novel tools for biochemists. Third, the utility of ortho-nitro phenyl alkynes to undergo [3+2] dipolar cycloadditions will be investigated. Previously, the feasibility of [4+2] cycloadditions has been demonstrated using this protocol and this new study will help to expand the scope of this cycloaddition approach to polyaromatic compounds. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Rich Carter of the Department of Chemistry at Oregon State University. Professor Carter's research efforts revolve around the development of novel methods for the construction of complicated polyaromatic compounds. Such compounds have considerable applications as ligands in the field of asymmetric catalysis as well as key pharmacophores in the pharmaceutical industry.