Synthetic and Mechanistic Investigations of CO-releasing Divalent Metal Acireductone and Flavonolate Complexes

无机，生物无机和有机化学计划支持教授丽莎M。Berreau的犹他州州立大学（USU）的研究，用于制备和表征二价金属酸还原酮和黄酮酸盐络合物。 一氧化碳（CO）最近被暗示在平滑肌松弛，并可能参与触发（或抑制）细胞凋亡。 的CO-释放，发生在这些配合物与氧治疗的机械途径阐明。 对CO调节和产生的理解可能使我们深入了解金属稳态与生物学中其他调节机制之间的联系。 本工作研究了C1（H）-取代acreductone配合物的结构，稳定性和反应性与镍（II）螯合的多齿吡啶为基础的配体和澄清的作用，单电子转移和自由基化学的金属配位acreductone的氧化。 研究生、本科生和高中生也参与了这项研究。 ACS学生联盟在USU的活动使学生与当地的小学，初中和高中学生接触。 Berreau教授和她的小组准备了实用的色谱实验，提供给犹他州洛根的中学科学教师。每年夏天，实验室都会接待两名来自当地特许高中的学生。

The Inorganic, Bioinorganic and Organometallic Chemistry Program supports Professor Lisa M. Berreau of Utah State University (USU) for the preparation and characterization of divalent metal acireductone and flavonolate complexes. Carbon monoxide (CO) has recently been implied in smooth muscle relaxation and may be involved in triggering (or inhibiting) apoptosis. The mechanistic pathways of the CO-release that occur upon treatment of these complexes with oxygen are elucidated. The understanding of CO regulation and production may give insight into links between metal homeostasis and other regulatory mechanisms in biology. This work investigates the structure, stability and reactivity of C1(H)-substituted acireductone complexes with Ni(II) chelated by multidentate pyridine-based ligands and clarifies the role of single electron transfer and radical chemistry in the oxidation of a metal-coordinated acireductone. An understanding of the role of the metal ion identity in directing the regiochemistry of the acireductone oxidation is also being developed.Graduate, undergraduate and high school students participate in the research. The activities of the ACS Student Affiliate Group at USU bring students in contact with the elementary, middle and high school students in the local area. Professor Berreau and her group prepare hands-on chromatography experiments that are made available to middle school science teachers in Logan, Utah. Two students from a local charter high school are hosted in the laboratory each summer.