Elucidation and Exploitation of Directed C-H Activation Reactions

有了这个新的奖项，有机和高分子化学计划支持布兰代斯大学化学系的Jin-Quan Yu教授的工作。 本研究将集中于催化和立体选择性的C-H活化反应的研究。 将开发合成上有用的导向基团以辅助C-H裂解步骤。这些导向基团将容易地转化为可用于合成转化的官能团。将设计提供C-H裂解过程的区域选择性和立体选择性的新型导向基团。 一个重要的目标是通过七元和八元环金属化过程选择性地活化远程C-H键。本项目将开发温和的、低成本的C-H官能化催化体系，以使廉价的、绿色氧化剂能够用于C-H催化活化反应。本项目将采用广泛的物理、有机和无机工具来深入研究这些催化反应。一些本科生将参与这些研究，作为他们的论文工作和教育的一部分。预计简单羧酸和胺衍生物的区域选择性和立体选择性官能化将为合成提供有用的起始材料，并且应该对材料科学和药物合成等领域产生重大影响。

With this new award, the Organic and Macromolecular Chemistry Program supports the work of Professor Jin-Quan Yu of the Chemistry Department at Brandeis University. This research will focus on the investigation of catalytic and stereoselective C-H activation reactions. Synthetically useful directing groups will be developed to assist the C-H cleavage step. These directing groups will be readily converted to functional groups that are useful for synthetic transformations. Novel directing groups that will afford regioselectivity and stereoselectivity of the C-H cleavage process will be designed. A significant goal is to activate remote C-H bonds selectively via seven- and eight- membered cyclometallation processes. Mild and cost-effective catalytic systems to achieve C-H functionalization will be developed in order to allow the use of cheap and green oxidants in catalytic C-H activation reactions.This project will employ a wide range of physical organic and inorganic tools to seek insights into these catalytic reactions. A number of undergraduate students will be involved in these studies as part of their thesis work and education. It is expected that regioselective and stereoselective functionalizations of simple carboxylic acid and amine derivatives will provide useful starting materials for synthesis and should have a major impact on areas such as material science and pharmaceutical synthesis.