New Methods to Prepare Carbon-Heteroatom and Carbon-Carbon Bonds

该提议包括从环境友好且容易获得的起始材料制备各种环状和非环状化合物。 路易的实验室最近发现了一个潜在的重要中间体在镍催化的交叉偶联反应。 环加成反应和交叉偶联反应的机理分析将继续进行。 在这些研究的同时，将合成反应性M-CO2中间体，并探索它们对其他底物的反应性，目的是将这些反应性模式纳入新的催化反应库。有了这个奖项，有机和大分子化学计划支持犹他州大学化学系的Janis Louie教授的研究。 Louie教授的研究工作围绕着开发用于形成环状和非环状化合物的简易过渡金属介导方法。 此外，还将评估利用二氧化碳等良性原料的新方法。该方法的成功开发将对制药和农业工业的合成产生影响。

This proposal encompasses the preparation of a variety of cyclic and acyclic compounds from environmentally friendly and readily available starting materials. The Louie's laboratory recently discovered a potentially important intermediate in Ni-catalyzed cross-coupling reactions. Mechanistic analysis of both cycloaddition reactions as well as cross-coupling reactions will be continued. Concurrent to these investigations, reactive M-CO2 intermediates will be synthesized and their reactivity toward other substrates will be explored with the intention of incorporating these reactivity patterns into the repertoire of new catalytic reactions.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Janis Louie of the Department of Chemistry at the University of Utah. Professor Louie's research efforts revolve around the development of facile transition metal-mediated methods for the formation of cyclic and acyclic compounds. In addition, new methods for utilizing benign starting materials such as carbon dioxide will be evaluated. Successful development of the methodology will have an impact on synthesis in the pharmaceutical and agricultural industries.