ADRF, vasoregulation and hypertension

本研究旨在明确高血压、肥胖和代谢综合征血管张力的外膜周调节。在概念层面上，该项目旨在证明血管周围脂肪组织作为“脂肪细胞衍生的舒张因子”（ADRF）的来源，其干扰的局部、旁分泌、血管活性作用导致这些疾病状态下的血管功能障碍。研究集中在硫化氢（H2S）、氢过氧二十碳四烯酸（HPETEs）和羟基环氧二十碳三烯酸（HETEs）作为ADRF的候选物;在肥胖、高血压和代谢综合征的动物模型中探索这些产物对外膜周血管调节的重要性。为了阐明所涉及的KCNQ钾通道基因的作用，将使用Kcnq基因缺陷小鼠。脂肪细胞的血管活性因子或其受体可能成为开发新型心血管药物的靶点。

This research project aims to define the periadventitial regulation of vascular tone in hypertension, obesity and metabolic syndrome. On a conceptual level, the project aims to demonstrate that the perivascular adipose tissue acts as a source of 'Adipocyte-derived relaxing factor' (ADRF) and its disturbed local, paracrine, vasoactive effects are causing vascular dysfunction in these disease states. The investigations are focused hydrogen sulfide (H2S), hydroperoxyeicosatetraenoic acids (HPETEs) and hydroxy-epoxyeicosatrienoic (HEETs) as candidates of ADRF; the importance of these products for the periadventitial vessel regulation is explored in animal models of obesity, hypertension and the metabolic syndrome. To clarify the role of involved KCNQ potassium channels gene Kcnq gene -deficient mice will be used. Vasoactive factors of adipocytes or their receptors could represent targets for the development of novel cardiovascular drugs.