Ross River virus - identification of virulence determinants in clinical isolates from across Australia

在澳大利亚，罗斯河病毒(RRV)是最常见的影响人类健康的昆虫传播病毒。1993至2008年间，确诊的RRV病例超过6万例。虽然这种疾病不是致命的，但它导致了严重的发病率，给个人、他们的家庭和社区带来了社会和经济代价。该项目有几个全国性的好处。它将阐明RRV毒株与人类疾病的严重程度之间是否有任何联系。它还将确定可以帮助公共卫生官员确定爆发的可能疾病后果的病毒标志物，并可能为设计抗病毒战略提供新的途径。

In Australia, Ross River virus (RRV) is the most common insect borne virus that affects human health. There were more than 60,000 confirmed cases of RRV between 1993 and 2008. While not fatal, the disease is responsible for significant morbidity that has both social and economic costs for the individual, their family and the community. The project has several national benefits. It will elucidate whether there is any association between RRV strain and the severity of human disease. It will also identify viral markers that could assist public health officials in determining likely disease outcomes of outbreaks and could provide new avenues for the design of antiviral strategies.