SBIR Phase I: Phage control of filamentous bacteria - A novel focused antimicrobial approach to counter microbial problems in municipal wastewater systems

该SBIR第一阶段项目将开发一种噬菌体技术，以补救和控制废水处理厂中产生泡沫的微生物。这项研究将包括分离有问题的发泡诺卡氏菌，分离能够杀死发泡诺卡氏菌的噬菌体，以及评估批培养测试系统中诺卡氏菌的噬菌体清除情况。这是废水处理中的一个重要问题，在废水系统中使用噬菌体控制泡沫的概念是创新的。拟议项目的更广泛/商业影响将是拟议技术的潜在应用。活性污泥法废水处理工艺很常见。如果操作条件不优化，就会出现微生物过度生长导致的问题泡沫。该项目将允许开发一种创新的解决方案，如果成功，应该具有重大的商业价值。

This SBIR Phase I project will develop a phage technology to remediate and control the foam-causing microorganisms at wastewater treatment plants. The research will include isolation of problematic foaming Nocardia species, isolation of phage capable of killing foaming Nocardia, and evaluation of phage clearing of Nocardia in batch culture test systems. This is an important issue in wastewater treatment and the concept of using phage for foam control in waste water systems is innovative.The broader/commercial impacts of the proposed project will be the potential applications of the proposed technology. Activated sludge wastewater treatment processes are common. Problematic foaming caused by excessive microbial growth occurs if the operation conditions are not optimized. The project will allow development of an innovative solution and if successful, should have significant commercial value.