MRI-R2 Acquisition of a 600 MHz NMR Spectrometer

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。来自密苏里大学圣路易斯分校化学和生物化学系的Spilling及其同事将获得一台600 MHz NMR光谱仪。该仪器将用于支持涉及合成化学以及蛋白质、DNA和其他生物大分子的结构和动力学的研究活动。具体例子如下：1）限制性内切酶结构和功能; 2）游离和脂质结合形式的PP 2C样ABI 1和Raf-like CTR 1的PA结合结构域的结构、动力学和功能; 3）Puf重复结构域-mRNA复合物的结构和构象以及mRNA降解; 4）淀粉样β肽的结构和生物活性; 5）HPV的抗病毒化合物; 6）加速铁从血清转移中的释放; 7）设计用于运输和用于药物递送的合成通道、胶囊和纳米管; 8）复杂糖结构的合成、形成机制、结构和构象; 9）手性非外消旋烯丙基羟基膦酸酯在合成复杂天然产物中的应用;和10）来自Si-H键活化反应的Pt-Si聚集体。核磁共振（NMR）光谱学是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。这些NMR研究的结果将对合成有机/无机化学、材料化学和生物化学产生影响。该仪器将成为教学和研究的一个组成部分。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).With this award from the Major Research Instrumentation (MRI) program Professor Christopher D. Spilling and colleagues from the Chemistry and Biochemistry Department at the University of Missouri-Saint Louis will acquire a 600 MHz NMR spectrometer. The instrument will be used to support research activities dealing with synthetic chemistry as well as structures and dynamics of protein, DNA and other biological macromolecules. Specific examples are: 1) restriction endonuclease structure and function; 2) structure, dynamics and function of PA-binding domains of PP2C-like ABI1 and Raf-like CTR1 in free and lipid-bound forms; 3) structure and conformations of Puf repeat domain-mRNA complexes and mRNA degradation; 4) structure and biological activity of the amyloid-beta peptide; 5) antiviral compounds for HPVs; 6) accelerating iron release from serum transferring; 7) synthetic channels, capsules, and nanotubes designed for transport and for drug delivery; 8) synthesis, mechanism of formation, structure, and conformation of complex glycostructures; 9) application of chiral, non-racemic allylic hydroxy phosphonates for the synthesis of complex natural products; and 10) Pt-Si aggregates from Si-H bond activation reactions.Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research.