Development of Titanium Catalysts and Multicomponent Coupling Strategies Applicable to Heterocyclic Synthesis

Aaron L.教授密歇根州立大学的Odom得到了化学系化学催化（CAT）项目的支持，以探索钛络合物的性质和反应性，重点是催化生产杂环化合物的新反应。主要的重点将是对氢胺化的炔和烯烃，这是原子经济的合成方法产生的C？N键。将研究在单一合成步骤中产生复杂有机化合物的多组分偶联反应以及用于多组分偶联化学的表面束缚催化剂系统的路线。钛基化学的优点包括钛？天然丰度高，无毒。本文综述了近年来发展的新型碳原子经济反应化学和催化剂。氮键的形成是高效、绿色合成各种氮杂环化合物的关键。这些氮杂环在影响我们日常生活的许多领域都有应用。例如，市场上大约80%的药物含有氮，许多是氮杂环的形式。这项研究预计将对制药和精细化工行业产生直接影响。参与这项研究的研究生和本科生以及博士后助理将接受化学催化和合成化学方面的优秀培训。

Professor Aaron L. Odom of Michigan State University is supported by the Chemical Catalysis (CAT) Program in the Division of Chemistry to explore the properties and reactivity of titanium complexes with a focus on new reactions for the catalytic production of heterocyclic compounds. The main focus will be on the hydroamination of alkynes and alkenes, which are atom-economical synthetic methodologies for the generation of C?N bonds. Multi-component coupling reactions that yield complex organic compounds in a single synthetic step as well as routes to surface-tethered catalyst systems for multicomponent coupling chemistry will be investigated. The advantages of titanium-based chemistry include titanium?s high natural abundance and lack of toxicity. The development of new atom-economical reaction chemistry and catalysts for C?N bond formation is critical for the efficient, green synthesis of a variety of nitrogen-based heterocycles. These nitrogen heterocycles have applications in many areas that impact our daily lives. For example, around 80% of the pharmaceuticals on the market contain nitrogen, many in the form of nitrogen heterocycles. This research is expected to have an immediate impact on the pharmaceutical and fine chemicals industry. Graduate and undergraduate students and postdoctoral associates involved in this research will receive excellent training in chemical catalysis and synthetic chemistry.