Scaffolds for bone tissue regeneration and use in orthopaedic applications

受损的关节不能自发修复，通常会导致关节炎。由先天性缺陷或疾病过程导致的骨缺损具有再生的挑战性，并且对我们的卫生系统构成了重大的财政负担。骨移植治疗被广泛使用，但具有相当大的缺点。这就需要支架为新骨提供临时支撑。然而，它们缺乏骨修复所需的综合物理/生物学特性。我们开发了具有改进的机械/生物学特性的新支架来模拟骨，这将导致骨损伤的新治疗方法。

Damaged joints do not repair spontaneously, often leading to arthritis. Bone defects resulting from congenital defects or disease processes are challenging to regenerate and represent a major financial burden to our health system. Bone graft treatments are widely used but have considerable drawbacks. This created a need for scaffolds to provide temporary support for new bone. However they lack the combined physical/biological properties necessary for bone repair. We developed new scaffolds with improved mechanical/biological properties to mimic bone which will lead to new treatments for bone damage.