IDR-Collaborative: Quantitative 3D Optical Tomographic Microscopy for Lung Cancer Diagnosis

1014813 Reeves该团队正在开发的显微镜工具将允许细胞及其细胞器的定量吸收和荧光3D成像，这可以首次与疾病诊断的临床标准相关联。该项目以两种重要的对比模式开发了3D定量显微镜的新领域，弥合了临床诊断和医学研究之间的差距。此外，通过定量CT成像进行疾病诊断的3D图像处理技术正在以独特的合作方式应用于显微镜。细胞生物学教科书将细胞描述为具有二维特征的平面。如果疾病诊断是3D的，并且对疾病发作更加定量和敏感，那么这些教科书可能会改变以更准确地表示细胞解剖结构。由于真正的3D显微镜的进步，教授学生细胞结构和功能可能会发生显着变化。 为细胞学家和分子生物学家提供定量工具将导致肺癌等致命疾病的早期诊断，并提高对疾病机制的理解。

1014813ReevesA microscopic tool being developed by this team will allow quantitative absorption and fluorescence 3D imaging of cells and their organelles which can be correlated to the clinical standards of disease diagnosis for the first time. This project develops new fields of 3D quantitative microscopy in two important contrast modes that bridge a gap between clinical diagnosis and medical research. In addition, the technology of 3D image processing from quantitative CT imaging for disease diagnosis is being applied to microscopy in a unique collaboration.Textbooks of cell biology depict a cell as flat with two-dimensional features. If disease diagnosis is 3D and more quantitative and sensitive to disease onset, then these textbooks will likely change to more accurately represent the cell anatomy. Teaching students on cellular structures and functions may be significantly changed due to advancements of true 3D microscopy. Providing cytologists and molecular biologists with quantification tools will result in earlier diagnosis of lethal diseases like lung cancer and improved understanding of the disease mechanisms.