SBIR Phase II: Food Antioxidants (AOs) With or Without Estrogenic Activity (EA)

这个小企业创新研究（SBIR）第二阶段项目将使用最先进的检测方法来检测抗氧化剂（AO）中的雌激素活性（EA）和抗EA。具有EA或抗EA（EA**）的AO等化学品会对健康产生不利影响，包括生殖和行为障碍以及某些癌症。尚未对AO进行EA** 检查，更不用说重新制定AO包以针对特定商业应用具有特定EA水平。该项目将评估10种额外的有机AO和15种EA-**Free/EA** 指定配方的EA**，这些配方由传统、有机、水溶性和油溶性AO组合而成，在暴露于常用应力时稳定。这些AO配方将被确定的合作伙伴用于生产不含EA** 或具有明确规定的EA** 水平的动物饲料、谷物和其他食品，为商业化和额外的专利提供明确的途径。对极低剂量的具有EA** 的化学品特别敏感，不应不加区别地摄入这些化学品。相反，其他条件（例如，绝经期症状、前列腺的某些癌症或异常）可通过具有受控水平的EA** 的化学品来改善。因此，该项目将通过在谷物和婴儿配方奶粉等产品中使用不含EA** 的AO或在健身饮料和绝经后妇女膳食补充剂等产品中使用指定EA ** AO，尽量减少无意消费具有EA** 的化学品的风险。

This Small Business Innovation Research (SBIR) Phase II project will use state-of-the-art assays to detect estrogenic activity (EA) and anti-EA in antioxidants (AOs). Chemicals like AOs that have EA or Anti-EA (EA**) produce adverse health effects, including reproductive and behavioral disorders and some cancers. AOs have not been examined for EA**, much less AO packages reformulated to have specific levels of EA for specific commercial applications. This project will assess the EA** of 10 additional organic AOs, and 15 EA-**Free/EA**-specified formulations made from combinations of conventional, organic, water-soluble, and oil-soluble AOs that are stable when exposed to common-use stresses. These AO formulations will be used by identified partners to produce animal feeds, cereals and other foodstuffs that are EA**-free or have well-specified levels of EA** providing a clear path to commercialization and additional patents.The broader impacts of this research are that fetal or juvenile mammals, including humans, are especially sensitive to chemicals having EA** at very low dosages and should not indiscriminately ingest such chemicals. Conversely, other conditions (e.g., menopausal symptoms, some cancers or abnormalities of the prostate) are ameliorated by chemicals having controlled levels of EA**. Hence, this project will minimize the risks of unintentional consumption of chemicals having EA** by using EA**-free AOs in products such as cereals and baby formulas or specified-EA** AOs in products such as fitness drinks and dietary supplements for post-menopausal women.