Development of nanoscale hydrogels for oral delivery of siRNA

该提案的目的是合成能够将小干扰RNA（siRNA）递送至疾病靶点（特别是沿着胃肠道的靶点）的聚阳离子纳米级水凝胶。该研究计划描述了一些变量的表征和优化，这些变量将最终影响水凝胶的适用性。使用pH响应性纳米凝胶载体口服siRNA有望改善各种胃肠道疾病的治疗，因为口服递送比静脉内和腹膜内注射更有效，疼痛更少。申请人管理的实验室有40%的女性和20%的少数民族学生。作为向K-12学生推广的一部分，申请人将提供10名高中生暑期实习机会。

1033746PeppasThe objective of this proposal is to synthesize polycationic nanoscale hydrogels capable of delivery of small interfering RNA (siRNA) to disease targets, specifically those along the gastrointestinal tract. The research plan describes the characterization and optimization of a number of variables that will ultimately affect the suitability of the hydrogel Oral delivery of siRNA using pH-responsive nanogel carriers promises to improve the treatment of various gastrointestinal diseases because oral delivery is more efficient and less painful than intravenous and intraperitonealI injections. The applicant manages a lab that has 40 % women and 20 % minority students. As part of the outreach to K-12 students, the applicant is offering 10 high school students summer internships.