Conference: 2011 RNA Editing Gordon Research Seminar and Conference to be held in Galveston, TX; January 8-14, 2011

该奖项支持将于2011年1月9日至14日在德克萨斯州加尔维斯顿的Galvez酒店举行的第8届戈登RNA编辑研究会议。该奖项还支持相关的戈登研究研讨会，研究生和博士后研究员参加2011年1月8日至9日在同一地点为他们组织的会议。这个一年两次的会议是唯一一个专门讨论RNA和DNA编辑和修改的定期会议。这次会议将聚集一小群科学家，既有公认的科学领袖，也有初级科学家，在一个随意的环境中，促进与会者之间的非正式讨论。为了促进编辑和修改社区之间的交流，会议方案以主题会议的形式组织，集中讨论共同感兴趣的问题。讲座将在上午和晚上举行，下午为非正式讨论、休闲活动和海报会议预留时间。智力上的优点。由于研究RNA和DNA编辑和修饰的不同过程的科学家面临着类似的理论和技术挑战，这些研究人员在一次会议上互动，在该领域的中心问题的背景下讨论他们最近的发现，这是一个巨大的好处。科学家将被鼓励以演讲或海报的形式展示他们未发表的成果。预计2011年会议将取得重要和令人振奋的突破，包括：发现催化多种类型编辑和修饰的新酶；确定多组分编辑和修饰机器的分子部分；精确定义来自各种生物的编辑或修饰酶的靶RNA和DNA的识别模式；确定RNA和DNA编辑和修饰酶的新目标；深入了解这些酶的作用机制；分析几种酶的结构，以及它们与底物结合以催化反应的机制；对编辑和修饰酶以及对其生物学很重要的底物RNA的生物合成和亚细胞运输有了新的理解；对编辑和修饰在生物系统中的不同作用有了新的见解；对编辑和修饰过程的起源和进化有了新的见解。参加这次会议的科学家将受益于听到相关系统的最新信息，这可以在他们自己的系统中激发新的见解和实验方法。此外，科学家还将从学习解决新问题的尖端方法中受益匪浅，包括最新的质谱学方法、深度测序方法、遗传学方法和生物信息学方法。会议的一个主要目标是通过及早传播未发表的结果、通过讨论该领域新出现的问题以及通过解释解决这些问题的新技术来促进发现和促进学习。这次会议是唯一一次对这一迅速增长的领域进行概述的预定会议。它提供了一个独特的机会来讨论新的假设和模型，交换关于新的实验策略的信息，为未来的项目产生想法，并发起合作。会议力求实现性别平衡和不同种族、不同地域的发言者群体。在37名确认发言的人中，有11人是女性，分别是联席主席和联席副主席。几位女性也将主持会议。此外，被邀请的演讲者和戈登研究研讨会的主席中有两人是少数民族。会议的另一个主要目标是鼓励初级科学家的参与。为了推广初级科学家，所有参与者都将被鼓励展示海报，组织者将从研究生和博士后研究员中选出至少七名，从初级教员中至少选出两名进行平台演讲。此外，还有四名已确认的特邀演讲者，他们是初级教职科学家。研究生研究研讨会为研究生和博士后研究员的教育和培训提供了进一步的机会。这个迷你科学会议有三个平台会议和一个海报会议，这些小组的与会者可以在理想的科学讨论环境中展示和讨论他们的结果。

This award supports the 8th Gordon Research Conference on RNA Editing, which will be held at the Hotel Galvez in Galveston, TX on January 9-14, 2011. The award also supports the associated Gordon Research Seminar at which graduate students and postdoctoral fellows partake in a meeting organized for and by them from January 8-9, 2011 at the same site. This biannual conference is the only regularly scheduled meeting devoted exclusively to RNA and DNA editing and modification. The conference will bring together a small group of scientists, both established scientific leaders and junior scientists, in a casual setting that fosters informal discussion among participants. To promote cross-fertilization between the editing and modification communities, the conference program is organized in thematic sessions that focus on questions of common interest. Talks will be presented in the mornings and evenings, with afternoons reserved for informal discussions, leisure activities, and poster sessions. Intellectual merits. Since scientists investigating the diverse processes of RNA and DNA editing and modification face similar theoretical and technical challenges, there is a huge benefit for these investigators to interact at a single meeting to discuss their recent findings in the context of the central questions in the field. Scientists will be encouraged to present their unpublished results as talks or posters. Important and exciting breakthroughs are expected to be presented at the 2011 meeting, including: the discovery of new enzymes that catalyze diverse types of editing and modification; the identification of molecular parts of multi-component editing and modifying machines; the precise definition of the mode of recognition of target RNAs and DNAs of editing or modifying enzymes from various organisms; the identification of new targets of RNA and DNA editing and modifying enzymes; insights into the mechanism of action of these enzymes; structural analysis of several enzymes, and of the mechanism by which they bind substrates to catalyze reactions; new understanding of the biosynthesis and subcellular trafficking of editing and modification enzymes and of substrate RNAs that are important for their biology; new insights into the diverse roles of editing and modification in biological systems; and new insights into the origin and evolution of editing and modification processes. Scientists attending this meeting will benefit from hearing the latest information in related systems, which can provoke new insights and experimental approaches in their own system. Furthermore, scientists will also benefit immensely by learning about the cutting edge methods by which new questions are addressed, including the latest mass spectrometry methods, deep sequencing methods, genetic approaches, and bioinformatic methods.Broader impacts. A major goal of the conference is to advance discovery and to promote learning by early dissemination of unpublished results, by discussion of emerging questions in the field, and by explanation of new techniques to address these questions. This conference is the only scheduled meeting that provides an overview of this rapidly growing field. It provides a unique opportunity to discuss new hypotheses and models, to exchange information about new experimental strategies, to generate ideas for future projects, and to initiate collaborations. The meeting strives for gender balance and an ethnically and geographically diverse group of speakers. Eleven of the thirty-seven confirmed speakers, the co-chair, and the co-vice chair are women. Several women will also chair sessions. In addition, two of the invited speakers and the chair of the Gordon Research Seminar are minorities. A further major goal of the conference is to encourage participation of junior scientists. To promote junior scientists, all participants will be encouraged to present posters, from which the organizers will choose at least seven from graduate students and postdoctoral fellows and at least two from junior faculty to present platform talks. In addition, there are four confirmed invited speakers who are junior faculty scientists. The Graduate Research Seminar offers a further opportunity for the education and training of graduate students and postdoctoral fellows. This mini-scientific meeting features three platform sessions and a poster session in which attendees in these groups can present and discuss their results in a setting ideal for scientific discussion.