CAREER: Molecular Recognition of Anions with Novel Macrocyclic Chemosensors

这项由化学部高分子、超分子和纳米化学计划以及化学测量和成像计划颁发的职业奖项支持MD教授的研究和教育活动。杰克逊州立大学化学和生物化学系的Alamgir Hossain将开发新的大环化学传感器，用于对环境和生物上重要的阴离子进行比色检测和选择性识别。该方法是使用环状多氮杂受体作为骨架来构建三个选定的化学传感器系列，包括(I)指示剂-间隔物受体，(Ii)带有氧化还原开关的双核金属络合物，以及(Iii)指示剂-置换分析。最终目标是在分子水平上更深入地理解导致选择性阴离子识别的因素。这项工作通过引入一系列新的结构组装的化学传感器，推动了阴离子识别化学领域的发展。该计划让研究生和本科生，特别是少数族裔，参与跨学科的研究和教育。教育活动旨在促进高中生和本科生早日参与科学。在夏季的几个月里，这个项目提供了让高中生和老师参与有意义的化学研究的机会。发展国际和跨学科合作是这个职业项目的关键组成部分，它提高了学生的研究能力，扩大了他们的教育。此外，还设计了一个名为《化学在自然界》的推广项目，旨在让K-12学生对化学感兴趣和理解。在侯赛因教授小组工作的学生将积极参加区域和国家会议，向更广泛的科学界介绍他们的研究成果，并在广泛发行和受人尊敬的期刊上发表成果。

This CAREER award by the Macromolecular, Supramolecular and Nanochemistry Program and the Chemical Measurement and Imaging Program of the Chemistry Division supports research and educational activities of Professor Md. Alamgir Hossain of the Department of Chemistry and Biochemistry at Jackson State University to develop new macrocyclic chemosensors for the colorimetric detection and selective recognition of environmentally and biologically important anions. The approach is to use cyclic polyaza-receptors as frameworks for the construction of three selected series of chemosensors including (i) indicator-spacer receptors, (ii) dinuclear metal complexes with redox switches, and (iii) indicator-displacement assays. The ultimate goal is aimed at deeper understanding of the factors responsible for selective anion recognition at the molecular level. This work advances the field of anion recognition chemistry by introducing a new series of architecturally assembled chemosensors. The program involves graduate and undergraduate students, particularly underrepresented minorities, in interdisciplinary research and education.The educational activities are to promote early involvement of high school and undergraduate students in science. During summer months, this project provides opportunities to engage high school students and teachers in meaningful chemical research. Developing international and interdisciplinary collaborations are key components of this CAREER project, which advance students' research capability and broaden their education. In addition, an outreach program 'Chemistry in Nature' is designed to make chemistry interesting and understandable to K-12 students. Students working in the group of Professor Hossain are expected to actively participate in regional and national meetings for presenting their research to the broader scientific community, and to publish results in widely circulated and respected journals.