Templated Synthesis and Applications of Cucurbituril Type Receptors

大分子、超分子和纳米化学（MSN）项目支持马里兰大学学院公园分校的Lyle Isaacs教授的工作，他的工作重点是葫芦[n]uril （CB[n]）分子容器化合物家族的合成和超分子化学的发展。虽然非官能团CB[n]化合物被超分子化学界广泛探索，但具有活性官能团的CB[n]衍生物的制备仍然是一个重大挑战。Isaacs小组正在开发强大的合成方法，用于定制合成单功能化CB[n]衍生物。这些衍生物将被用于多种目的，包括固相色谱固定，刺激反应分子机器的制备，以及促进生物分子在水中的二聚化，用于诊断和传感应用。艾萨克斯小组还开发了一系列免费下载的视频，用于在万维网上发布，这些视频基于本科有机化学中的挑战性问题，展示了一个实践化学家如何解决问题。集装箱在日常生活中非常重要，包括保存食品和将物品运送到特定地点。分子容器为分子做同样的事情，构成了家用产品和药物配方的重要成分。Isaacs小组开发的化合物和程序将通过提供一系列具有活性官能团的容器化合物，使其能够纳入先进的功能系统，从而影响学术和工业科学。该计划鼓励本科生和来自代表性不足群体的学生参与化学研究。免费提供的网络视频展示了一位化学家解决本科有机化学中具有挑战性的问题，有望提高全球本科社区的学习成果。

The Macromolecular, Supramolecular and Nanochemistry (MSN) Program supports the work of Professor Lyle Isaacs at the University of Maryland College Park which focuses on the development of the synthetic and supramolecular chemistry of the cucurbit[n]uril (CB[n]) family of molecular container compounds. Although unfunctionalized CB[n] compounds are being widely explored by the supramolecular chemistry community, the preparation of CB[n] derivatives displaying reactive functional groups is still a major challenge. The Isaacs group is developing robust synthetic methods for the tailor-made synthesis of monofunctionalized CB[n] derivatives. These derivatives will be explored for a variety of purposes including their immobilization to solid phases for chromatography, for the preparation of stimuli responsive molecular machines, and to promote the dimerization of biomolecules in water for diagnostic and sensing application. The Isaacs group is also developing a series of freely downloadable videos for world wide web distribution based on challenging problems in Undergraduate Organic Chemistry that illustrate how a practicing chemist solves problems.Containers are tremendously important in everyday life including the preservation of foodstuffs and the shipping of items to specific locations. Molecular containers do the same things for molecules and constitute vital ingredients in household products and pharmaceutical formulations. The compounds and procedures developed by the Isaacs group will impact both academic and industrial science by providing a series of container compounds bearing reactive functional groups that allow their incorporation into advanced functional systems. This program encourages the participation of undergraduates and students from under-represented groups in chemical research. Freely available web videos showing a chemist solving challenging problems in undergraduate organic chemistry promises to enhance the learning outcome of the global undergraduate community.