Multifunctional Hybrid Porous Nanoparticles for Controlled Drug Release

ID：MPS/DMR/BMAT（7623）1207019 主要研究者：韦斯，莎伦·奥格：范德比尔特大学多孔硅（PSi）是一种很有前途的药物载体，由于其可调的孔隙率、生物相容性、生物降解性和特别大的比表面积，可用于药物装载和控制释放。 与脂质体或胶束药物递送载体不同，PSi可以通过PI最近开发的压印技术制成各种尺寸和形状。 该提案的目的是探索用于治疗局部病理的多功能多孔微米和纳米颗粒。 该研究的具体目标是：（1）了解多孔硅颗粒（PSP）的形状和大小对细胞摄取和选择性的影响，（2）研究智能表面附着化学，以实现负载治疗肽的细胞内位点特异性释放，以及（3）探索超声诱导药物释放机制和压电功能化PSP的可行性。该研究结合了材料科学，生物医学工程，电气工程和物理学的互补学科的科学和工程方法，以实现能够对抗一些最具社会和经济破坏性的医疗条件的药物输送平台。 该计划的综合教育目标涉及参与研究生和本科生研究人员接触纳米科学的跨学科性质和基于团队的研究氛围。 研究小组的成员选择将强调增加性别和少数民族的参与，通过与现有的NSF赞助的范德比尔特-菲斯克-特拉华州I立方计划在材料科学，纳米科学与工程REU计划的范德比尔特研究所，以及SWE，NSBE和SHPE的范德比尔特分会的协调促进。 教育K-12外展将侧重于开发基于探究的学习活动，以教授纳米科学概念，并在纳什维尔冒险科学中心的学校访问和活动中分享。

ID: MPS/DMR/BMAT(7623) 1207019 PI: Weiss, Sharon ORG: Vanderbilt UniversityTitle: Multifunctional Hybrid Porous Nanoparticles for Controlled Drug ReleaseINTELLECTUAL MERIT: Porous silicon (PSi) is a promising drug delivery vehicle owing to its tunable porosity, biocompatibility, biodegradability, and exceptionally large specific surface area, which can be exploited for drug loading and controlled release. Unlike liposomal or micellar drug delivery vehicles, PSi can be fabricated into a vast range of sizes and shapes by an imprinting technique recently developed by the PI. The aim of this proposal is to explore multifunctional porous micro- and nanoparticles for the treatment of localized pathologies. The specific objectives of the research are: (1) understanding the impact of porous silicon particle (PSP) shape and size on cellular uptake and selectivity, (2) investigating smart surface attachment chemistries to enable intracellular, site-specific release of loaded therapeutic peptides, and (3) exploring the viability of an ultrasonically-induced drug release mechanism and piezoelectric-functionalized PSPs.BROADER IMPACTS: This research combines scientific and engineering methods of the complementary disciplines of materials science, biomedical engineering, electrical engineering, and physics for the realization of a drug delivery platform capable of combating some of the most socially and economically devastating medical conditions. The integrated educational goals of the plan involve the exposure of participating graduate and undergraduate researchers to the interdisciplinary nature of nanoscience and a team-based research atmosphere. Member selection of the research team will emphasize increasing the participation of gender and ethnic minorities, as facilitated through coordination with the existing NSF-sponsored Vanderbilt-Fisk-Delaware State I-cubed program in materials science, the Vanderbilt Institute of Nanoscale Science and Engineering REU program, and the Vanderbilt chapters of SWE, NSBE, and SHPE. Educational K-12 outreach will focus upon the development of inquiry-based learning activities to teach nanoscience concepts, to be shared during school visits and events at the Nashville Adventure Science Center.