RUI-Effect of pH on Chiral Recognition of Amino Acid Based Micelles

在这项由化学系化学测量和成像计划资助的奖项中，德克萨斯农工大学科珀斯克里斯蒂的Fereshteh Billiot教授和迦太基学院的Kevin Morris教授以及他们的本科生研究人员将获得支持，以研究pH对氨基酸衍生表面活性剂对其他物种的手性识别的影响。利用溶液相核磁共振方法，结合其他物理表征方法，研究pH对这些表面活性剂的影响。表面活性剂在毛细管电泳手性混合物分离中显示出良好的拟固定相应用前景。手性分子是具有“手”对称性的分子。它们在结构上的不同只是在某种意义上它们是彼此的镜像。由于它们具有相同的化学结构，除了它们的利手性外，手性异构体的混合物很难分离。比利奥特教授、莫里斯教授和他们的学生对设计分离手性异构体的新方法很感兴趣。这项工作在药物的提纯和分析中具有重要的应用。从事这一项目的本科生将在对这些有趣的表面活性剂体系进行物理化学表征方面获得有用的经验。作为这项工作的一部分，Billiot教授将继续努力鼓励来自代表性不足群体的学生从事科学事业

In this award, funded by the Chemical Measurement and Imaging Program of the Division of Chemistry, Professor Fereshteh Billiot of Texas A & M University Corpus Christi and Professor Kevin Morris of Carthage College and their undergraduate student researchers will be supported to investigate the effect of pH on chiral recognition by amino acid derived surfactants towards other species. The effect of pH on these surfactants will be studied with solution-phase nuclear magnetic resonance (NMR) methods, combined with other physical characterization methods. The surfactants show promise as pseudo-stationary phases in capillary electrophoresis separations of chiral mixtures. Chiral molecules are molecules that have "handed" symmetry. They differ in structure from each other only in the sense that they are mirror images of each other. Since they have identical chemical structures, except for their handedness, mixtures of the chiral isomers are difficult to separate. Professors Billiot, Morris and their students are interested in designing new ways to separate chiral isomers. This work has important applications in purification and analysis of pharmaceuticals. The undergraduate students working on this project will gain useful experience in carrying out the physic-chemical characterization of these interesting surfactant systems. As part of this work, Prof. Billiot will continue her strong efforts at encouraging students from underrepresented groups to pursue careers in the sciences