Collaborative Research: Redox Behavior of Heme-NOx Models - A Vehicle for Outreach and Discovery

化学部的化学合成计划支持分别在俄克拉荷马州和南伊利诺伊大学爱德华兹维尔的里希特-阿多和肖小组之间的合作研究。 本研究利用先进的电化学技术，探讨以氮氧化物为配体的血红素模型的氧化还原和化学行为。 还研究了氮氧化物配体对金属卟啉氧化还原行为的影响，以及卟啉骨架和反式配体对金属结合的NO基团的化学反应性的影响。 光谱电化学，同时使用计时光阻和计时电流技术，将被用来获得不稳定的氧化还原中间体的紫外-可见光谱，以帮助他们的表征。氮氧化物存在于城市大气和生活系统中。 金属中心，如那些存在于金属卟啉作为血红素模型，调节这些氮氧化物的化学。 该项目将揭示新合成的含有氮氧化物作为配体的复合物的观察到的化学和氧化还原行为。 子项目的不同复杂性是OU-SIUE合作的理想选择，因为它为博士和博士生提供了适当的培训。一个机构（RUI）和一个RUI（SIUE）。 与少数民族服务机构的教育互动将得到加强，对哥伦比亚大学和SIUE的向上发展方案也将作出富有成效的贡献。

The Chemical Synthesis Program of the Division of Chemistry supports the collaborative research between the Richter-Addo and Shaw groups at the University of Oklahoma and Southern Illinois University Edwardsville, respectively. This research employs advanced electrochemistry techniques to probe the redox and chemical behavior of heme models bearing nitrogen oxides as ligands. Also investigated are the effects that nitrogen oxide ligands have on metalloporphyrin redox behavior, and the effects of the porphyrin scaffold and the trans ligands have on the chemical reactivity of the metal-bound NO groups. Spectroelectrochemistry, using simultaneous chronoabsorptometry and chronoamperometry techniques, will be utilized to derive the UV-vis spectra of unstable redox intermediates to aid in their characterization. Nitrogen oxides are present in the urban atmosphere and in living systems. Metal centers, such as those present in metalloporphyrins as heme models, regulate the chemistry of these nitrogen oxides. This project will shed insight on both the observed chemistry and redox behavior of newly synthesized complexes containing nitrogen oxides as ligands. The varied complexity of the sub-projects is ideal for the OU-SIUE collaboration, as it provides training appropriate for students at both a Ph.D. institution (OU) and an RUI (SIUE). Educational interactions with a minority-serving institution will be strengthened, as will productive contributions to the Upward Bound programs at both OU and SIUE.