NEW METHODS TO PREPARE CARBON-HETEROATOM AND CARBON-CARBON BONDS

有了这个奖项，化学合成计划是支持教授贾尼斯路易的化学系在犹他州大学的研究。 该项目的重点是从环境友好和容易获得的起始材料制备各种环状和非环状化合物。此前，路易教授的实验室已经开发出了介导不饱和烃和杂累积烯环加成反应的过渡金属催化剂。 本研究的重点是阐明这些环加成反应的机理，以开发更有效的金属介导的反应。 扩大这些金属催化的环加成反应的范围也将是一个焦点。 此外，最近发现的镍催化的交叉偶联反应中的重要中间体的进一步研究将被追求。 Louie教授的研究工作围绕着开发用于形成环状和非环状化合物的简易过渡金属介导方法。 此外，将评估利用良性起始材料的新方法。 该方法的成功开发将对任何需要合成分子的活动领域产生影响，例如制药，化学，农业以及生物和化学研究。 此外，该项目还将为本科预科到博士后水平的学生提供培训机会。

With this award, the Chemical Synthesis program is supporting the research of Professor Janis Louie of the Department of Chemistry at the University of Utah. This project focuses on the preparation of a variety of cyclic and acyclic compounds from environmentally friendly and readily available starting materials. Previously, transition metal catalysts that mediate the cycloaddition of unsaturated hydrocarbons and heterocumulenes had been developed in Professor Louie's laboratory. This project focuses on the elucidation of the mechanism of these cycloaddition reactions in order to develop more efficient metal-mediated reactions. Expanding the scope of these metal catalyzed cycloaddition reactions will also be a focus. In addition, further studies of a recently discovered important intermediate in Ni-catalyzed cross-coupling reactions will be pursued. Professor Louie's research efforts revolve around the development of facile transition metal-mediated methods for the formation of cyclic and acyclic compounds. In addition, new methods for utilizing benign starting materials will be evaluated. Successful development of the methodology will have an impact on any area of activity in which the synthesis of molecules is needed, such as the pharmaceutical, chemical, agricultural industry, and biological and chemical research. In addition, this project will provide training opportunities for students from the pre-undergraduates to post-doctoral level.