Multimodal music training strategy to reverse maladaptive cortical reorganization associated with chronic tinnitus

该项目的核心目标是开发一种个性化的、多模态的音乐训练策略，并对其进行行为和电生理评估，以治疗调性耳鸣。为了抑制刺激，我们会利用音乐，这是病人自己通过弹钢琴产生的。生成的音乐将被实时过滤（即在其他抑制中，以个人耳鸣频率为中心的频带），并在训练期间通过耳机收听。单独修改的音乐旨在通过区域（即参与耳鸣感知的非听觉皮层区域）抑制性神经元网络的加强，部分或完全逆转耳鸣感知基础上的适应性不良皮层重组结果。由于(i)训练的多模态（即同时涉及运动和不同的大脑感觉区域），（ii）动机（这是可以预期的，因为患者会播放他们选择的最喜欢的音乐），以及（iii）必须集中在所有相关模态上的注意力，我们期望最大的训练效果。通过纳入合适的对照患者组，探讨多模态因素和注意事项对训练效果的影响。次要目标是(i)分析与听觉幻像感知相关（即音调耳鸣，兹威克音）的自发皮层活动，以及（ii）通过MEG研究耳鸣集中注意力对皮层活动的影响。

The core aim of this project is the development and the behavioral and electrophysiological evaluationof an individually tailored, multimodal music training strategy for the treatment of tonal tinnitus. Astraining stimulus, we will utilize music, which will be generated by the patients themselves by means ofplaying piano. The generated music will be filtered in real-time (i.e. amongst others suppression of afrequency band that is centered at the individual tinnitus frequency) and listened to via headphonesduring the training. The individually modified music is intended to partly or fully reverse maladaptivecortical reorganization outcomes that underlie the tinnitus perception by means of the regional (i.e. inauditory cortex regions involved into tinnitus perception) strengthening of inhibitory neuronal networks.Due to the (i) multimodality of the training (i.e. simultaneous involvement of motor as well as differentsensory brain regions), the (ii) motivation (which can be expected because the patients will playfavorite music of their choice), and the (iii) attention that necessarily has to be focused on all involvedmodalities, we expect maximum training efficacy. By means of the inclusion of suitable control patientsgroups, the roles of the factors multimodality and attention for training efficacy will be investigated.Secondary objectives are (i) the analysis of auditory phantom perception-related (i.e. tonal tinnitus,Zwicker tone) spontaneous cortical activity, as well as (ii) the investigation of effects of tinnitus-focused attention on cortical activity by means of MEG.