Support for the 2nd Penn State Bioinorganic Workshop

第二届宾夕法尼亚州立大学生物无机研讨会将于2012年5月31日至6月9日在宾夕法尼亚州立大学的大学公园校园举行。 拟议的研讨会旨在为学生和博士后提供完整的沉浸式培训体验。 生物无机化学的领域是多样的，包括各种各样的科学学科，包括遗传学，分子生物学，生物化学，生物信息学，分析化学和物理化学。研讨会将包括讲座主题，如：（1）分子生物学原理;（2）配位化学原理;（3）量子化学原理;（4）瞬态动力学方法;（5）EPR光谱学;（6）ENDOR/ESEEM光谱学;（7）光谱参数计算;（8）共振拉曼光谱学;（9）X射线吸收光谱学;（10）穆斯堡尔谱;（11）磁性圆二色光谱;（12）质谱;（13）作为机械探针的同位素效应;（14）蛋白质电化学;（15）X射线晶体学;（16）生物电子转移。 此外，还包括“动手”实验室培训方面。 将提供以下实践课程：（1）SF吸收光谱;（2）FQ方法;（3）EPR光谱;（4）穆斯堡尔光谱;（5）ENDOR/ESEEM光谱;（6）共振拉曼光谱;（7）质谱;（8）空气敏感酶的纯化;（9）定点诱变;（10）蛋白质电化学;以及（11）在宾夕法尼亚州立大学校园的Breazeale核反应堆进行的低温还原实验。更广泛的影响本次会议的许多领域将直接关系到当今社会面临的核心挑战。 在生物无机化学的基础合作研究可能会提供重要的洞察力，合理设计的化学/工业过程。例如，通过更好地了解固氮酶，改进了现代农业的关键工艺--哈伯-博世工艺。该研讨会将为培养生物无机颗粒学的学生和博士后做出重要贡献。大约80名年轻研究人员将沉浸在对这一研究领域至关重要的各种方法和概念中，从而接受的培训无疑将比他们在任何一个研究小组中可能接受的培训更广泛。

Intellectual Merit The 2nd Penn State Bioinorganic Workshop will be held on the University Park campus of The Pennsylvania State University from May 31-June 9, 2012. The proposed workshop aims to provide a complete immersion training experience to students and postdocs. The field of bioinorganic chemistry is diverse, and includes a wide variety of scientific disciplines, including genetics, molecular biology, biochemistry, bioinformatics, analytical chemistry, and physical chemistry. The workshop will include lecture topics, such as, (1) principles of molecular biology; (2) principles of coordination chemistry; (3) principles of quantum chemistry; (4) transient state kinetic methods; (5) EPR spectroscopy; (6) ENDOR/ESEEM spectroscopy; (7) computation of spectroscopic parameters; (8) resonance Raman spectroscopy; (9) X-ray absorption spectroscopy; (10) Mössbauer spectroscopy; (11) magnetic circular dichroism spectroscopy); (12) mass spectrometry; (13) isotope effects as mechanistic probes; (14) protein electrochemistry; (15) X-ray crystallography; and (16) biological electron transfer. In addition, a "hands-on" laboratory training aspect is also included. The following hands-on sessions will be offered: (1) SF-absorption spectroscopy; (2) the FQ method; (3) EPR spectroscopy; (4) Mössbauer spectroscopy; (5) ENDOR/ESEEM spectroscopy; (6) resonance Raman spectroscopy; (7) mass spectrometry ; (8) purification of air-sensitive enzymes; (9) site-directed mutagenesis; (10) protein electrochemistry; and (11) cryoreduction experiments at the Breazeale Nuclear Reactor on the Penn State campus. Broader ImpactsMany areas of this meeting will directly relate to central challenges facing society today. Fundamental collaborative research in bioinorganic chemistry may provide important insight for rational design of chemical/industrial processes. An example includes the improvement of the Haber Bosch process, a crucial process for modern agriculture, by a better understanding of the enzyme nitrogenase.This workshop will make important contributions to training of students and postdocs in bioinorgranics. Approximately 80 young researchers will immerse themselves in a wide variety of methods and concepts central to this research area, thus receiving training that will undoubtedly be broader than they could possibly receive in any one research group.