I-Corps: Device for Producing the Non-antibiotic Antimicrobial Hypothiocyanite (HTC) for Use in Food Safety

这个项目是考虑使用多个董事会和方案官员的投入。它包括I-Corps Cognizant计划官员的口头投入和特定主题董事会的书面投入（包括在下面）。理事会的意见：PI开发了一种新型的合成工艺，并获得了专利，该工艺用于生产抗菌化学品次硫氰酸盐（HTC）。如果能够廉价制造，HTC有潜力在食品安全市场上进行商业应用。目前，美国的肉类生产商使用次氯酸盐来防止大肠杆菌污染，但这种分子会产生致癌物质，因此在欧洲市场已被禁止。PI的技术，由美国国家科学基金会资助的化学部生产，应该允许HTC以一定的规模和价格生产，使其成为次氯酸盐的安全替代品。该团队由PI，迈克尔阿什比，谁是化学教授在俄克拉荷马州大学。创业带头人罗伯特·弗里毕业于俄克拉荷马州大学的工程物理专业。他目前是美国经济财富创造中心的研究员。罗伯特在商业化方面有经验。J. Boyd Nolan是创业导师。他在波音公司工作过，并为几家成功的初创公司工作过。我认为这个团队对有机会积极参与I-Corps计划感到兴奋，并将从中受益。由于这个原因，以及该发现是在一个具有商业意义的领域，我建议将该提案用于I-Corps基金。Cognizant计划主任建议：该I-Corps项目建立在NSF支持的以前工作的基础上。以前的赠款是：CHE-0503984 CHE-0911328有明确的市场需求，该团队拥有证明I-Corps支持合理的领域知识。如果成功转型为营利性实体，可能会产生明显的影响。50 000美元的预算符合第一军团的需要。学术团队已经与I-Corps项目主管讨论了这一努力，我们一致建议支持这个I-Corps项目。MPS将使用以下代码支持这项工作：030000008023

This project was considered using input from multiple directorates and program officers. It included verbal input from the I-Corps Cognizant Program Officers and written input from the Topic-Specific Directorate (included below). The intellectual merits as well as the broader impacts were considered and the team was invited to submit this proposal.Directorate Input:The PI has developed and patented a novel synthetic process to make the antimicrobial chemical, hypothiocyanate (HTC). HTC has the potential to be commercially used in the food safety market if it can be made cheaply. Currently meat producers in the US use hypochlorite to prevent ecoli contamination, but this molecule can produce carcinogens and, thus, has been banned in European markets. The PIs technology, produced under funding from a NSF grant from the Chemistry Division, should allow HTC to be made at a scale and price that would make it a safe alternative to hypochlorite.The team consists of the PI, Michael Ashby, who is a Professor of Chemistry at the University of Oklahoma. The Entrepreneurial Lead, Robert Free, is a graduate of the University of Oklahoma's (OU) Engineering Physics program. He is currently a Fellow in OU's Center for the Creation of Economic Wealth. Robert has experience in commercialization efforts. J. Boyd Nolan is the Entrepreneurial Mentor. He has experience at Boeing and has worked for several successful startups. It is my opinion that this team is excited about the opportunity to actively participate in the I-Corp Program and will benefit from it. For this reason and the fact that the discovery is in a commercially significant field, I recommend this proposal for I-Corp funding.Cognizant Program Director Recommendation:This I-Corps project builds upon previous work supported by NSF.The Previous Grants were:CHE-0503984CHE-0911328There is a clearly-defined market need and the team possesses the domain knowledge to justify I-Corps support. If successfully transitioned to a for-profit entity, there is potential for clear impact. The budget for $50,000 conforms to I-Corps requirements. The Academic team has discussed this effort with the I-Corps program directors and it is our unanimous recommendation to support this I-Corps project. This effort will be supported by MPS using the following codes:030000008023