CAREER: Biophysical Mechanisms of Pulmonary Surfactant and its Interactions with Therapeutic Agents

肺表面活性物质(PS)通过使肺泡表面张力降至接近零的水平，在维持正常的呼吸力学中起着至关重要的作用。这项建议的研究目标是利用实验和计算相结合的方法来研究PS和PS-药物相互作用的生物物理机制。目的1.研究天然肺表面活性物质的生物物理机制。目的2.研究天然肺表面活性物质和治疗药物(皮质类固醇)之间的相互作用。拟议的研究包括以新的方式使用的最新方法的组合，以获得对所涉及的机制的完整了解。这项工作对普通公众很重要，因为它将为PS在健康和疾病中所起的作用提供新的见解，从而促进美国的新生儿护理。这项提案的主要教育目标是提高夏威夷原住民、太平洋岛民和其他代表性不足群体的学生的参与度和成就率。该协会还将与迪梅斯基金会夏威夷分会合作，向夏威夷青年传播预防和管理早产的基本知识。

AbstractPI Yi Zuo1254795Pulmonary surfactant (PS) plays a crucial role in maintaining the normal respiratory mechanics by reducing the alveolar surface tension to near-zero. The research goal of this proposal is to study the biophysical mechanisms of PS and PS-drug interactions, using combined experimental and computational methods. There are 2 objectives: Objective 1. Study of biophysical mechanisms of natural pulmonary surfactant. Objective 2. Study of interactions between natural pulmonary surfactant and therapeutic agents (corticosteroids).The proposed studies include combinations of state-of-the-art methods that are being used in novel ways to gain a complete understanding of the mechanisms involved. This work is important to the general public because it will provide new insight into the role that PS plays in health and disease, thus advancing neonatal care in the United States. The primary educational goal of this proposal is to improve participation and success of Native Hawaiians, Pacific Islanders, and students from other underrepresented groups. The PI will also collaborate with the March of Dimes Foundation Hawaii Chapter to disseminate basic knowledge of prevention and management of preterm birth to Hawaiian youth.