SYNTHESIS OF P-CHIRAL ORGANOPHOSPHORUS COMPOUNDS

在化学部化学合成计划资助的这个项目中，德克萨斯基督教大学化学系的Jean-Luc Montchamp教授将探索在磷原子上形成手性化合物（P-手性有机磷化合物）的方法的发展。 获得P-手性化合物仍然是一个主要的合成挑战，化学家在很大程度上仍然依赖于稀有的商业上可获得的但昂贵的化合物来开发他们的各种催化方法。 本研究旨在探索P-手性磷化合物的合成方法。 虽然存在多种方法，但迄今为止，每种方法都受到显著的限制，例如高成本，有限的范围和可扩展性，延长的时间投资或复杂的实验条件。 P-手性化合物的实际路线可能对不对称选择性催化产生重大影响，因为手性膦在不对称选择性催化中是普遍存在的。 更有效的对映选择性催化将对所有需要合成手性分子的化学领域产生影响，例如制药，农业和化学工业。 此外，该项目将提供优秀的同事培训，从本科研究参与者到博士后，包括那些历史上在物理科学中代表性不足的群体。

In this project funded by the Chemical Synthesis Program of the Chemistry Division, Professor Jean-Luc Montchamp of the Department of Chemistry at Texas Christian University will explore the development of methods for the formation of compounds that are chiral at the phosphorus atom (P-chiral organophosphorus compounds). Access to P-chiral compounds remains a major synthetic challenge, and chemists largely still rely on rare commercially available but expensive compounds for the development of their various catalytic methodologies. This proposal aims at the general and practical preparation of P-chiral phosphorus compounds. Although a variety of methods exists, to date every single method suffers from significant limitations such as high cost, limited scope and scalability, extended time-investment, or complicated experimental conditions. Practical routes to P-chiral compounds could have a major impact on enantioselective catalysis, as chiral phosphines are ubiquitous in enantioselective catalysis. More effective enantioselective catalysis will have an impact in all areas of chemistry where the synthesis of chiral molecules is needed such as the pharmaceutical, agricultural, and chemical industries. Additionally, this project will provide excellent training of coworkers, from undergraduate research participants to post-doctoral, including those from groups historically underrepresented in the physical sciences.