Transfer Hydrogenative Hydroaminoalkylation and Imine Addition

在这个由化学部门化学合成项目资助的项目中，德克萨斯大学奥斯汀分校化学和生物化学系的Michael J. Krische教授将探索通过氢胺烷基化形成C-C键的新策略。在这种过程中，胺和非饱和反应物之间的氢交换产生瞬时亚胺-有机金属对，在没有化学计量副产物的情况下结合形成亚胺加成产物。与经典亚胺添加不同，直接胺-不饱和C-C偶联(a)绕过了化学计量主基团有机金属的离散制备，从而避免了摩尔量金属废物的产生，(b)避免了亚胺的离散形成，以提高阶梯经济性。这些研究可以通过基本化学原料的直接C-C耦合，为重要的商品化学品（塑料、泡沫、制药和农用化学品）提供更有效、无副产品的途径。无副产品的化学制造催化方法从源头上消除了化学废物，因此对环境无害。此外，该项目将为学生提供优秀的培训，从本科预科到博士后，包括那些来自历史上在科学领域代表性不足的群体。

In this project funded by the Chemical Synthesis Program of the Chemistry Division, Professor Michael J. Krische of the Department of Chemistry and Biochemistry at the University of Texas at Austin will explore new strategies for the formation of C-C bonds via hydroaminoalkylation. In such processes, hydrogen exchange between amines and pi-unsaturated reactants generates transient imine-organometal pairs that combine to form products of imine addition in the absence of stoichiometric byproducts. Unlike classical imine additions, direct amine-unsaturated C-C couplings (a) bypass discrete preparation of stoichiometric main-group organometallics and, consequently, circumvent generation of molar quantities of metallic waste, and (b) avoid discrete imine formation to enhance step-economy. These studies could offer more efficient, byproduct-free routes to important commodity chemicals (plastics, foams, pharmaceutical and agrochemicals) through the direct C-C coupling of basic chemical feedstocks. Byproduct-free catalytic methods for chemical manufacturing eliminate chemical waste at the source and, hence, are environmentally benign. In addition, this project will provide excellent training of students, from pre-undergraduate to post-doctoral, including those from groups historically underrepresented in the sciences.