Synthesis, Mechanistic Investigations, and Applications of Transition Metal Enolates for Asymmetric Synthesis

在这个由化学系化学合成计划资助的项目中，加州理工学院化学与化学工程系的Brian M.Stoltz教授将研究他的实验室中发现的一个重要的不对称催化烷基化反应中高对映选择性的起源，并将所获得的知识应用于开发一个广泛的平台，用于对映体选择性过渡金属烯酸酯官能化化学的开发。所描述的工作可以提供前所未有的途径，获得含有立体产生中心的简单化学积木，并可能被学术界和工业界的合成化学家广泛采用。这一独特的工具集合可以使化学家在将这些技术应用于超出当前方法范围的化合物和物质方面超越最先进的水平。除了这笔拨款中描述的现场实验室科学外，这里提出的科学将直接影响加州理工学院科学家的教育，而他们获得的技能和专业知识将广泛影响整个社会，因为他们也将进入学术界、工业和政府的富有成效的职业生涯。最后，正在进行的针对年轻学生(K-6)的教学和外展工作将影响下一代学生的生活和决定。

In this project funded by the Chemical Synthesis Program of the Chemistry Division, Professor Brian M. Stoltz of the Division of Chemistry and Chemical Engineering at the California Institute of Technology will investigate the origins of high enantioselectivity in an important asymmetric catalytic alkylation reaction discovered in his laboratory, and apply the knowledge gained toward the development of a broad platform for enantioselective transition metal enolate functionalization chemistry. The work described could provide unprecedented access to simple chemical building-blocks containing stereogenic centers, and could be widely adopted by synthetic chemists in both academia and industry. This unique collection of tools could enable chemists to push beyond the state-of-the-art in applying such technologies to compounds and substances that are beyond the scope of the current methods. In addition to the on-site, laboratory science described in this grant, the science proposed herein will directly impact the education of scientists at the California Institute of Technology, while the skill set and expertise they gain will broadly impact society-at-large as they too move on to productive careers in academia, industry, and government. Finally, ongoing teaching and outreach efforts with young students (K-6) will impact the lives and decisions of the next generation of students.