Gated Molecular Encapsulation in Water

化学学部的大分子、超分子和纳米化学项目支持俄亥俄州立大学Jovica D. Badjic教授对有机和水介质中门控分子篮的机制和操作的研究。该计划的第一个目标是揭示表征立体选择性门控封装动力学的规则，并研究门控过程对(a)完成立体异构体的动力学解析和(b)控制化学反应结果的重要性。该计划的第二个目标是探索水介质中门控封装的动力学。主要目的是开发水溶性篮子，并研究/优化其作用机理。疏水效应与定向非共价相互作用协同作用，有望为调节有效药物在水中的包封动力学和递送提供通道。最后，研究了分子包封和门控在促进水中有机催化转化方面的优势，以开发水超分子催化剂。对复杂化学系统中分子易位及其控制的基本理解将有助于在未来开发更有效的催化剂，将原料化学品转化为有价值的产品。此外，探索以精确速度提供强效药物的新方法将通过改变当前的制药技术使社会受益。该计划旨在教育研究生和博士后学生在超分子化学领域之外寻找研究机会。此外，拟议的工作旨在加强各级文化和性别多样性，并增加俄亥俄州立大学代表性不足的少数民族和女性研究人员的数量。

The Macromolecular, Supramolecular and Nanochemistry Program of the Chemistry Division supports studies of professor Jovica D. Badjic of the Ohio State University on elucidating mechanisms and operation of gated molecular baskets in organic and aqueous media. The first objective of the program is to disclose rules that characterize the kinetics of stereoselective gated encapsulation and investigate the importance of the process of gating for (a) completing a kinetic resolution of stereoisomers and (b) controlling the outcome of chemical reactions. The second objective of the program centers on exploring the kinetics of gated encapsulation in aqueous media. In particular, the aim is to develop water-soluble baskets and study/optimize their mechanism of action. The hydrophobic effect, in synergy with directional non-covalent interactions, is expected to permit the gating for modulating the encapsulation kinetics and delivery of useful drugs in water. Finally, the benefit of molecular encapsulation and gating for promoting organocatalytic transformations in water is to be investigated for developing aqueous supramolecular catalysts.A fundamental understanding of the translocation of molecules and its control in complex chemical systems will help developing more effective catalysts for the conversion of feedstock chemicals into valuable products in future. In addition, exploring new ways for a delivery of potent drugs at a precise rate will benefit society by transforming current pharmaceutical technologies. The proposed program is designed to educate graduate and postdoctoral students to identify research opportunities beyond the field of supramolecular chemistry. In addition, the proposed work aims to enhance cultural and gender diversity at all levels and increase the number of underrepresented minorities and women researchers at the Ohio State University.