INSPIRE Track 2: Public Health, Nanotechnology, and Mobility (PHeNoM)

PI: Erickson， David提案：1343058标题：INSPIRE Track 2：公共卫生、纳米技术和流动性（PHeNoM）该INSPIRE奖汇集了传统上由以下研究领域支持的研究领域：工程理事会（ENG）化学、生物工程、环境和运输系统司（CBET）的生物光子学和纳米生物传感项目；电气、通信和网络系统部（ECCS）的通信、电路和传感系统项目；社会、行为和经济科学局（SBE）社会和经济科学司科学、技术和社会项目；以及计算机与信息科学工程理事会（CISE）信息与智能系统部（IIS）的智能健康与福祉项目。公共卫生、纳米技术和流动性（PHeNoM）项目支持的科学和技术可能最终导致广泛获取从芯片实验室技术获得的卫生信息。该研究项目可以通过实现疾病的早期检测，降低公共医疗保健服务的成本，并允许个人更好地控制自己的健康，从而改变国内的医疗保健格局。这种进步需要将卫生保健设备部署的社会和技术背景结合起来。这种集成是通过收集技术早期版本的反馈并根据最初的反馈修改未来的设计来完成的。通过解释反馈并指导开发过程的研究工作，可以促进反馈和设计之间的迭代。一项新的教育工作使技术最终向市场转移成为可能，该工作涉及课程作业、商业计划制定、种子前赠款研讨会以及与移动医疗领域现有初创企业的合作的独特组合。技术描述纳米技术和微流体技术的进步使芯片实验室设备的发展成为可能，这些设备可以精确地检测和量化蛋白质、遗传和其他疾病的生化标志物。目前可用的个性化诊断设备仅限于需要频繁监测的情况（如糖尿病患者的血糖）或“双重”结果（如怀孕）。PHeNoM项目的目标是证明利用无处不在的智能手机技术可以从根本上改变芯片实验室技术的部署，并表明移动平台上物理传感和分子分析的融合可以使医疗诊断比单独使用任何一种技术提供更多的信息。为了实现这些目标，研究人员正在集中精力开发和部署三种系统，这些系统可能会对美国的个性化医疗保健产生直接影响：用于长期压力管理的stress - phone，用于血液检测的营养意识的nutrition - phone，以及用于监测HIV+患者病毒载量的Hema-Phone。除了这些技术的直接优点之外，这个项目更广泛的优点是展示了新的“生物信息移动”诊断，它将移动性、计算、物理传感和生物分子分析的优势交织在一起。

PI: Erickson, David Proposal: 1343058 Title: INSPIRE Track 2: Public Health, Nanotechnology, and Mobility (PHeNoM) This INSPIRE award brings together research areas traditionally supported by: the Biophotonics and Nanobiosensing Programs in the Chemical, Bioengineering, Environmental, and Transport Systems Division (CBET) of the Engineering Directorate (ENG); the Communications, Circuits and Sensing Systems Program in the Electrical, Communications and Cyber Systems Division (ECCS) of the ENG Directorate; the Science, Technology and Society Program in the Social and Economical Sciences Division of the Social, Behavioral and Economic Sciences Directorate (SBE); and the Smart Health and Wellbeing Program in the Information and Intelligent Systems Division (IIS) of the Computer & Information Science Engineering Directorate (CISE). Significance The science and technology enabled by the Public Health, Nanotechnology and Mobility (PHeNoM) project may ultimately lead to widespread access to health information obtainable from lab-on-chip technology. This research project could alter the domestic healthcare landscape by enabling earlier-stage detection of disease, reducing the cost of public healthcare delivery, and allowing individuals to take better control of their own well-being. Such advances require the integration of the social and technical contexts of health care device deployment. This integration is accomplished by gathering feedback on early versions of the technology and modifying future designs based on that initial feedback. Iterations between feedback and design are facilitated by research efforts that interpret the feedback and guide the development process. The ultimate transfer of the technology to the marketplace is enabled by a new education effort that involves a unique combination of coursework, business plan development, pre-seed grant workshops, and collaborations with existing start-ups in the mobile health space. Technical Description Advancements in nanotechnology and microfluidics have enabled the development of lab-on-chip devices that can detect and quantify protein, genetic, and other biochemical markers of diseases with precision. Currently-available personalized diagnostic devices are limited to conditions that require either frequent monitoring (e.g. glucose for diabetics) or "binary" results (e.g. pregnancy). The goals of the PHeNoM program are to demonstrate that deployment of lab-on-chip technology can be fundamentally altered by taking advantage of ubiquitous smartphone technology and show that the fusion of physical sensing and molecular assays on mobile platforms enable healthcare diagnostics that are more informative than either technology alone. To meet these aims, the investigators are focusing their efforts on developing and deploying three systems that may have an immediate impact on advancing personalized healthcare in the United States: a Stress-Phone for long term stress management, a Nutri-Phone for bloodwork-enabled nutritional awareness, and a Hema-Phone for monitoring viral loading in HIV+ patients. Beyond the immediate merits of these technologies, the broader merit of this project is the demonstration of new "bioinfo-mobile" diagnostics that intertwine the advantages of mobility, computation, physical sensing, and biomolecular assays.