CAREER: Wearable, self-powered biosensors for disease detection and health monitoring

这项研究旨在开发创新的可穿戴、自供电的纺织生物系统，用于原位健康监测和疾病检测。该技术将直接集成到织物和服装上，以提供轻便、不显眼的可穿戴传感系统，不会影响穿戴者的移动性、舒适性或注意力。智力优势：可穿戴传感器技术的当前能力限于测量生理参数（例如心率、血压、呼吸率），并且很少关注用于生物分子检测的可穿戴传感器。这项拟议的研究将实现新的可穿戴，自供电的纺织生物传感器，为BioMEMS，可穿戴传感和即时诊断提供创新范例。由体液激活的纺织品电池用于按需发电是一个根本性的创新概念，它将为基于非传统材料（即织物，尿液，汗液）的新型电池的设计和操作提供新的科学见解。广泛影响：拟议项目具有广泛的影响，并可能通过以下方式改变医疗保健和改善人类福祉：（1）提供持续健康监测的经济手段，（2）通过早期疾病检测支持预防医学，（3）降低医疗保健成本及其对世界经济的负担，以及（4）提供适合资源有限国家使用的低成本诊断。PI将开发新的教育和推广活动，以加强MSU的BioMEMS研究，向K-12学生和教师推广STEM学科，并增加妇女和未代表的少数民族学生的参与。活动将包括：1）开发新的本科/研究生课程（ME 491：BioMEMS传感和集成），这将加强MSU现有的MEMS课程; 2）招募和指导工程专业的学生，特别是女性和代表性不足的少数民族，在生物医学研究;和3）为初中/高中教师和学生开发新的外展计划，以促进STEM领域的K-12学生的后代。

The proposed research aims to develop innovative wearable, self-powered textile biosystems for in situ health monitoring and disease detection. This technology will be integrated directly onto fabrics and garments to provide lightweight, unobtrusive wearable sensing systems that do not compromise wearer mobility, comfort or attention. Intellectual Merit: The current capabilities of wearable senosr technology are limited to measuring physiological parameters (e.g. heart rate, blood pressure, respiratory rate) and little attention has been directed toward wearable sensors for biomolecular detection. This proposed research will realize new wearable, self-powered textile biosensors offering innovative paradigms in BioMEMS, wearable sensing and point-of-care diagnostics. Textile batteries activated by body fluids for on-demand electricity generation is a fundamentally innovative concept which will provide new scientific insights into the design and operation of novel batteries based on nontraditional materials (i.e. fabric, urine, sweat). Broad Impact: The proposed project has a broad impact and will potentially transform healthcare and improve human well-being by (1) providing an economical means for continuous health monitoring, (2) supporting preventive medicine through early disease detection, (3) reducing healthcare costs and its burden on world economies, and (4) offering low cost diagnostics suitable for use in resource-limited countries. The PI will develop new educational and outreach activities that will enhance BioMEMS research at MSU, promote STEM disciplines to K-12 students and teachers, and increase participation by women and unrepresented minority students. Activities will include: 1) Developing a new undergraduate/graduate course (ME 491: BioMEMS Sensing and Integration) that will strengthen the existing MEMS curriculum at MSU; 2) Recruiting and mentoring engineering students, particular women and underrepresented minorities, in biomedical research; and 3) Developing new outreach programs for middle/high school teachers and students to promote STEM fields to future generations of K-12 students.