Development of computer-based decision support tools using population pharmacokinetic/pharmacodynamic models

糖尿病是一种流行病，给发达国家和发展中国家的卫生系统带来巨大负担。澳大利亚每年在这种疾病上的花费估计为350亿美元，随着诊断率的提高，费用将上升。此外，糖尿病的负担在土著澳大利亚人中更为突出。我们打算为医生开发一种方便用户的计算机辅助决策工具，以改善对非土著和土著澳大利亚人的这种疾病的管理。一旦建立，该工具将在其他卫生保健领域得到应用，这些领域需要支持，以便为关键药物做出明智的剂量决定，并有可能减少慢性病的经济和社会影响。

Diabetes is an epidemic that presents an enormous burden to health systems of both developed and developing nations. Australia spends an estimated $35 billion on the condition annually, with costs set to rise with increasing diagnosis rates. Additionally, the burden of diabetes is more prominent in indigenous Australians. We intend to improve management of this disease in non-indigenous and indigenous Australians by development of a user-friendly computer-based decision support tool for doctors. Once established, this tool will have applications in other fields of health care where support is needed to make informed dosing decisions for critical medications and have the potential to reduce financial and social impacts of chronic disease.