Novel roles for importin alpha proteins in the nucleus

该项目将提供有关细胞功能变化如何受到importin（IMP）α蛋白影响的基本新信息，包括基因转录的变化和细胞内转运的改变。这些研究结果将为国家优先领域提供信息，包括健康老化，特别是细胞应激反应的有效老化，以及在健康，基因完整的精子生产背景下的健康生活开端。该项目汇集了一个国际团队来研究一种现象，这种现象对正常发育过程和细胞/组织对疾病状况的反应有着新的认识。

The project will provide fundamental new information about how changes in cell function are influenced by importin (IMP) alpha proteins, both through changes in gene transcription and through alterations to intracellular transport. These findings will inform areas of national priority that include Aging Well, Aging Productively with specific regard to cellular stress responses, and A Healthy Start to Life in the context of production of healthy, genetically intact sperm. This project draws together an international team to investigate a phenomenon with implications for new understanding of normal developmental processes and the response of cells/tissues to disease conditions.