MRI: Acquisition of a High-Resolution Mass Spectrometer

凭借主要研究仪器（MRI）和化学研究仪器和设施（CRIF）计划的这一奖项，夏威夷大学将获得集成超高效液相色谱仪（UHP-LC）和高分辨率质谱仪（HRMS）与四极飞行时间（Q-TOF）。该系统将用于分析从各种来源获得的材料的成分，包括从化学反应、天然产物和生物来源获得的样品。液相色谱系统（LC）将混合物分离成其单个组分。然后质谱（MS）将组分电离，并通过测量离子的质荷比（m/z）来确定其质量。选定的配置将能够进行准确的质量测定，并能够解析和表征复杂混合物的组分。这是一种广泛使用的分析工具，用于确定混合物或材料的成分。该仪器将被学生用于他们的研究，用先进的现代仪器训练他们。实验室课程的学生将接受培训，使用这个工具为他们进入化学和相关领域的研究生学习和职业生涯做好准备。质谱系统将用于研究领域，包括：（a）合成磷烯基配体及其相应的过渡金属络合物在小分子活化、均相催化和替代能源过程中的应用;（B）追求天然产物的全合成和新的成键过程的开发;（c）研究产生C-S键的自由基S-腺苷甲硫氨酸（SAM）酶的机制;（d）研究弹性蛋白;（e）开发膜蛋白表达和结晶技术;（f）开发生物活性小分子的全合成和合成，以及（g）鉴定复杂生物样品中的小分子。

With this award from the Major Research Instrumentation (MRI) and Chemistry Research Instrumentation and Facilities (CRIF) programs, the University of Hawaii will acquire an integrated ultra-high-performance liquid chromatograph (UHP-LC) and high-resolution mass spectrometer (HRMS) with quadrupole time-of-flight (Q-TOF). The system will be used to analyze the composition of materials obtained from various sources including samples obtained from chemical reactions, natural products and biological sources. The liquid chromatography system (LC) separates a mixture into its individual components. Mass Spectrometry (MS) then ionizes the components and determines their mass by measuring the mass to charge ratio (m/z) of the ions. The selected configuration will enable accurate mass determination, with the capability to resolve and characterize the components of complex mixtures. This is a widely used analytical tool to identify the composition of a mixture or material. The instrument will be used by students in their research, training them with sophisticated, modern instrumentation. Students in laboratory courses will be trained to use this tool preparing them for their advancement into graduate study and careers in chemistry and allied fields. The mass spectrometry system will be used in research including areas such as (a) synthesizing phosphaalkene-based ligands and the application of their corresponding transition metal complexes to problems in small molecule activation, homogeneous catalysis, and alternative energy processes; (b) pursuing total synthesis of natural products and the development of new bond-forming processes; (c) studying mechanisms of radical S-adenosylmethionine (SAM) enzymes that generate C-S bonds; (d) studying elastin protein; (e) developing technologies for membrane protein expression and crystallization; (f) developing total synthesis and synthesis of bioactive small molecules and (g) identifying small molecules in complex biological samples.